Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/150970
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dc.contributor.authorLiow, Sing Shyen_US
dc.contributor.authorChee, Pei Linen_US
dc.contributor.authorOwh, Callyen_US
dc.contributor.authorZhang, Kangyien_US
dc.contributor.authorZhou, Yubinen_US
dc.contributor.authorGao, Fengen_US
dc.contributor.authorLakshminarayanan, Rajamanien_US
dc.contributor.authorLoh, Xian Junen_US
dc.date.accessioned2021-06-14T00:47:53Z-
dc.date.available2021-06-14T00:47:53Z-
dc.date.issued2019-
dc.identifier.citationLiow, S. S., Chee, P. L., Owh, C., Zhang, K., Zhou, Y., Gao, F., Lakshminarayanan, R. & Loh, X. J. (2019). Cationic poly([R]-3-hydroxybutyrate) copolymers as antimicrobial agents. Macromolecular Bioscience, 19(4), 1800466-. https://dx.doi.org/10.1002/mabi.201800466en_US
dc.identifier.issn1616-5187en_US
dc.identifier.other0000-0001-8118-6502-
dc.identifier.urihttps://hdl.handle.net/10356/150970-
dc.description.abstractPoly([R]-3-hydroxybutyrate) (PHB), a natural biodegradable polyester, has attracted much attention as a new biomaterial because of its sustainability and good biocompatibility. In this study, it is discovered that PHB can be conveniently functionalized to obtain a number of platform chain architectures that may provide a wide range of functional copolymers. In a transesterification reaction, linear (di-hydroxylated) and star shaped (tri- and tetra-hydroxylated) PHB oligomers are synthesized, followed by copolymerization with 2-(dimethylamino)ethyl methacrylate and quaternization with benzyl bromide to afford antimicrobial properties. The antimicrobial activities of the quaternary salts against clinically relevant pathogens on the interactions with outer and cytoplasmic membranes, lethal mechanisms, multipassage resistance, and synergy effect with antibiotics are investigated. Cationic PHB copolymers show effectiveness as antimicrobial agents, with minimum inhibitory concentration values 0.24-0.65 µm (or µmol dm⁻³ ) (or 32-128 µg mL⁻¹ ) against Gram-positive and Gram-negative bacteria. Modifying the copolymer architectures into star shapes results in enhanced effectiveness to disrupt the membrane integrity. Synergistic effects are attained for all the quaternized PHB derivatives when they are used together with tobramycin. Multipassage resistance does not occur in both the linear and star derivatives against Gram-negative bacteria after 20 passages.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.language.isoenen_US
dc.relation1325400026en_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.rights© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.en_US
dc.subjectEngineering::Materialsen_US
dc.titleCationic poly([R]-3-hydroxybutyrate) copolymers as antimicrobial agentsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doi10.1002/mabi.201800466-
dc.identifier.pmid30694604-
dc.identifier.scopus2-s2.0-85060767666-
dc.identifier.issue4en_US
dc.identifier.volume19en_US
dc.identifier.spage1800466en_US
dc.subject.keywordsAntimicrobial Copolymeren_US
dc.subject.keywordsBiodegradableen_US
dc.description.acknowledgementThe authors would like to express gratitude to the A*STAR Personal Care Grant (Project no.1325400026) for support of this project.en_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
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