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|Title:||Minimally invasive electroceutical catheter for endoluminal defect sealing||Authors:||Singh, Manisha
Varela, Claudia E.
Horvath, Markus A.
Tan, Nigel Chew Shun
Ong, Chee Bing
Schermerhorn, Marc L.
Roche, Ellen T.
Steele, Terry W. J.
|Keywords:||Science::Medicine||Issue Date:||2021||Source:||Singh, M., Varela, C. E., Whyte, W., Horvath, M. A., Tan, N. C. S., Ong, C. B., Liang, P., Schermerhorn, M. L., Roche, E. T. & Steele, T. W. J. (2021). Minimally invasive electroceutical catheter for endoluminal defect sealing. Science Advances, 7(14), eabf6855-. https://dx.doi.org/10.1126/sciadv.abf6855||Project:||MOE2014-T2-2-100
|Journal:||Science Advances||Abstract:||Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in vivo and ex vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 millimeters in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudo-aneurysms/fistulas to bioelectrodes toward electrophysiological mapping.||URI:||https://hdl.handle.net/10356/151011||ISSN:||2375-2548||DOI:||10.1126/sciadv.abf6855||Rights:||© 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||IGS Journal Articles|
Updated on Sep 22, 2021
Updated on Sep 22, 2021
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