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Title: Minimally invasive electroceutical catheter for endoluminal defect sealing
Authors: Singh, Manisha
Varela, Claudia E.
Whyte, William
Horvath, Markus A.
Tan, Nigel Chew Shun
Ong, Chee Bing
Liang, Patric
Schermerhorn, Marc L.
Roche, Ellen T.
Steele, Terry W. J.
Keywords: Science::Medicine
Issue Date: 2021
Source: Singh, M., Varela, C. E., Whyte, W., Horvath, M. A., Tan, N. C. S., Ong, C. B., Liang, P., Schermerhorn, M. L., Roche, E. T. & Steele, T. W. J. (2021). Minimally invasive electroceutical catheter for endoluminal defect sealing. Science Advances, 7(14), eabf6855-.
Project: MOE2014-T2-2-100
Journal: Science Advances
Abstract: Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in vivo and ex vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 millimeters in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudo-aneurysms/fistulas to bioelectrodes toward electrophysiological mapping.
ISSN: 2375-2548
DOI: 10.1126/sciadv.abf6855
Rights: © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:IGS Journal Articles

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