Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151045
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dc.contributor.authorPhua, Siew Chengen_US
dc.contributor.authorTan, Yu Linen_US
dc.contributor.authorKok, Alison Maun Yengen_US
dc.contributor.authorSenol, Esraen_US
dc.contributor.authorChiam, Christine Jin Huien_US
dc.contributor.authorLee, Chun-Yaoen_US
dc.contributor.authorPeng, Yanminen_US
dc.contributor.authorLim, Auriel Theodora Jacobeaen_US
dc.contributor.authorMohammad, Hasanen_US
dc.contributor.authorLim, Jing-Xuanen_US
dc.contributor.authorFu, Yuen_US
dc.date.accessioned2021-06-25T06:39:34Z-
dc.date.available2021-06-25T06:39:34Z-
dc.date.issued2021-
dc.identifier.citationPhua, S. C., Tan, Y. L., Kok, A. M. Y., Senol, E., Chiam, C. J. H., Lee, C., Peng, Y., Lim, A. T. J., Mohammad, H., Lim, J. & Fu, Y. (2021). A distinct parabrachial-to-lateral hypothalamus circuit for motivational suppression of feeding by nociception. Science Advances, 7(19), eabe4323-. https://dx.doi.org/10.1126/sciadv.abe4323en_US
dc.identifier.issn2375-2548en_US
dc.identifier.urihttps://hdl.handle.net/10356/151045-
dc.description.abstractThe motivation to eat is not only shaped by nutrition but also competed by external stimuli including pain. How the mouse hypothalamus, the feeding regulation center, integrates nociceptive inputs to modulate feeding is unclear. Within the key nociception relay center parabrachial nucleus (PBN), we demonstrated that neurons projecting to the lateral hypothalamus (LHPBN) are nociceptive yet distinct from danger-encoding central amygdala–projecting (CeAPBN) neurons. Activation of LHPBN strongly suppressed feeding by limiting eating frequency and also reduced motivation to work for food reward. Refined approach-avoidance paradigm revealed that suppression of LHPBN, but not CeAPBN, sustained motivation to obtain food. The effect of LHPBN neurons on feeding was reversed by suppressing downstream LHVGluT2 neurons. Thus, distinct from a circuit for fear and escape responses, LHPBN neurons channel nociceptive signals to LHVGluT2 neurons to suppress motivational drive for feeding. Our study provides a new perspective in understanding feeding regulation by external competing stimuli.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.language.isoenen_US
dc.relation1530700142en_US
dc.relation.ispartofScience Advancesen_US
dc.rights© 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).en_US
dc.subjectScience::Medicineen_US
dc.titleA distinct parabrachial-to-lateral hypothalamus circuit for motivational suppression of feeding by nociceptionen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.organizationSingapore Bioimaging Consortium, A*STARen_US
dc.identifier.doi10.1126/sciadv.abe4323-
dc.description.versionPublished versionen_US
dc.identifier.pmid33962958-
dc.identifier.scopus2-s2.0-85105631394-
dc.identifier.issue19en_US
dc.identifier.volume7en_US
dc.identifier.spageeabe4323en_US
dc.subject.keywordsBrainen_US
dc.subject.keywordsNeuronsen_US
dc.description.acknowledgementThis work was supported by an A*STAR Investigatorship provided by the Biomedical Research Council (BMRC) of A*STAR (1530700142 to Y.F.).en_US
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