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dc.contributor.authorAng, Marcusen_US
dc.contributor.authorWong, Chee Waien_US
dc.contributor.authorHoang, Quan V.en_US
dc.contributor.authorCheung, Gemmy Chui Mingen_US
dc.contributor.authorLee, Shu Yenen_US
dc.contributor.authorChia, Audreyen_US
dc.contributor.authorSaw, Seang Meien_US
dc.contributor.authorOhno-Matsui, Kyokoen_US
dc.contributor.authorSchmetterer, Leopolden_US
dc.identifier.citationAng, M., Wong, C. W., Hoang, Q. V., Cheung, G. C. M., Lee, S. Y., Chia, A., Saw, S. M., Ohno-Matsui, K. & Schmetterer, L. (2019). Imaging in myopia : potential biomarkers, current challenges and future developments. British Journal of Ophthalmology, 103(6), 855-862.
dc.description.abstractMyopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal neovascularisation detection, while multimodal imaging is important for monitoring treatment response. However, imaging the eye with high myopia accurately has its challenges and limitations, which are important for clinicians to understand in order to choose the best imaging modality and interpret the images accurately. In this review, we present the current imaging modalities available from the anterior to posterior segment of the myopic eye, including the optic nerve. We summarise the clinical indications, image interpretation and future developments that may overcome current technological limitations. We also discuss potential biomarkers for myopic progression or development of complications, including basement membrane defects, and choroidal atrophy or choroidal thickness measurements. Finally, we present future developments in the field of myopia imaging, such as photoacoustic imaging and corneal or scleral biomechanics, which may lead to innovative treatment modalities for myopia.en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.relation.ispartofBritish Journal of Ophthalmologyen_US
dc.rights© 2019 The Author(s). Published by BMJ. All rights reserved.en_US
dc.titleImaging in myopia : potential biomarkers, current challenges and future developmentsen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.subject.keywordsOptical Coherence Tomographyen_US
dc.subject.keywordsChoroidal Neovascularizationen_US
dc.description.acknowledgementThis study was funded by Singapore Imaging Eye Network (SIENA) from the Singapore National Medical Research Council (NMRC).en_US
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Appears in Collections:LKCMedicine Journal Articles

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