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https://hdl.handle.net/10356/151118
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DC Field | Value | Language |
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dc.contributor.author | Moloudi, Reza | en_US |
dc.contributor.author | Oh, Steve | en_US |
dc.contributor.author | Yang, Chun | en_US |
dc.contributor.author | Teo, Kim Leng | en_US |
dc.contributor.author | Lam, Alan Tin-Lun | en_US |
dc.contributor.author | Warkiani, Majid Ebrahimi | en_US |
dc.contributor.author | Naing, May Win | en_US |
dc.date.accessioned | 2021-07-29T10:35:06Z | - |
dc.date.available | 2021-07-29T10:35:06Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Moloudi, R., Oh, S., Yang, C., Teo, K. L., Lam, A. T., Warkiani, M. E. & Naing, M. W. (2019). Scaled-up inertial microfluidics : retention system for microcarrier-based suspension cultures. Biotechnology Journal, 14(5), 1800674-. https://dx.doi.org/10.1002/biot.201800674 | en_US |
dc.identifier.issn | 1860-6768 | en_US |
dc.identifier.uri | https://hdl.handle.net/10356/151118 | - |
dc.description.abstract | Recently, particle concentration and filtration using inertial microfluidics have drawn attention as an alternative to membrane and centrifugal technologies for industrial applications, where the target particle size varies between 1 µm and 500 µm. Inevitably, the bigger particle size (>50 µm) mandates scaling up the channel cross-section or hydraulic diameter (DH > 0.5 mm). The Dean-coupled inertial focusing dynamics in spiral microchannels is studied broadly; however, the impacts of secondary flow on particle migration in a scaled-up spiral channel is not fully elucidated. The mechanism of particle focusing inside scaled-up rectangular and trapezoidal spiral channels (i.e., 5-10× bigger than conventional microchannels) with an aim to develop a continuous and clog-free microfiltration system for bioprocessing is studied in detail. Herein, a unique focusing based on inflection point without the aid of sheath flow is reported. This new focusing mechanism, observed in the scaled-up channels, out-performs the conventional focusing scenarios in the previously reported trapezoidal and rectangular channels. Finally, as a proof-of-concept, the utility of this device is showcased for the first time as a retention system for a cell-microcarrier (MC) suspension culture. | en_US |
dc.description.sponsorship | Agency for Science, Technology and Research (A*STAR) | en_US |
dc.language.iso | en | en_US |
dc.relation | U18‐B‐017SU SIMT/18‐410006 | en_US |
dc.relation.ispartof | Biotechnology Journal | en_US |
dc.rights | © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. | en_US |
dc.subject | Engineering::Bioengineering | en_US |
dc.title | Scaled-up inertial microfluidics : retention system for microcarrier-based suspension cultures | en_US |
dc.type | Journal Article | en |
dc.contributor.school | School of Mechanical and Aerospace Engineering | en_US |
dc.contributor.research | Singapore Institute of Manufacturing Technology | en_US |
dc.identifier.doi | 10.1002/biot.201800674 | - |
dc.identifier.pmid | 30791214 | - |
dc.identifier.scopus | 2-s2.0-85065832755 | - |
dc.identifier.issue | 5 | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.spage | 1800674 | en_US |
dc.subject.keywords | Inertial Microfluidics | en_US |
dc.subject.keywords | Mesenchymal Stem Cells | en_US |
dc.description.acknowledgement | R.M. would like to thank the SINGA scholarship sponsorship by A*STAR graduate academy, Singapore. This work was supported by Singapore Institute of Manufacturing Technology A*STAR Grant U18‐B‐017SU SIMT/18‐410006. M.E.W. would like to acknowledge the support of the Australian Research Council via Discovery Project Grant (DP170103704). | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | MAE Journal Articles |
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