Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMoloudi, Rezaen_US
dc.contributor.authorOh, Steveen_US
dc.contributor.authorYang, Chunen_US
dc.contributor.authorTeo, Kim Lengen_US
dc.contributor.authorLam, Alan Tin-Lunen_US
dc.contributor.authorWarkiani, Majid Ebrahimien_US
dc.contributor.authorNaing, May Winen_US
dc.identifier.citationMoloudi, R., Oh, S., Yang, C., Teo, K. L., Lam, A. T., Warkiani, M. E. & Naing, M. W. (2019). Scaled-up inertial microfluidics : retention system for microcarrier-based suspension cultures. Biotechnology Journal, 14(5), 1800674-.
dc.description.abstractRecently, particle concentration and filtration using inertial microfluidics have drawn attention as an alternative to membrane and centrifugal technologies for industrial applications, where the target particle size varies between 1 µm and 500 µm. Inevitably, the bigger particle size (>50 µm) mandates scaling up the channel cross-section or hydraulic diameter (DH > 0.5 mm). The Dean-coupled inertial focusing dynamics in spiral microchannels is studied broadly; however, the impacts of secondary flow on particle migration in a scaled-up spiral channel is not fully elucidated. The mechanism of particle focusing inside scaled-up rectangular and trapezoidal spiral channels (i.e., 5-10× bigger than conventional microchannels) with an aim to develop a continuous and clog-free microfiltration system for bioprocessing is studied in detail. Herein, a unique focusing based on inflection point without the aid of sheath flow is reported. This new focusing mechanism, observed in the scaled-up channels, out-performs the conventional focusing scenarios in the previously reported trapezoidal and rectangular channels. Finally, as a proof-of-concept, the utility of this device is showcased for the first time as a retention system for a cell-microcarrier (MC) suspension culture.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.relationU18‐B‐017SU SIMT/18‐410006en_US
dc.relation.ispartofBiotechnology Journalen_US
dc.rights© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.en_US
dc.titleScaled-up inertial microfluidics : retention system for microcarrier-based suspension culturesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.researchSingapore Institute of Manufacturing Technologyen_US
dc.subject.keywordsInertial Microfluidicsen_US
dc.subject.keywordsMesenchymal Stem Cellsen_US
dc.description.acknowledgementR.M. would like to thank the SINGA scholarship sponsorship by A*STAR graduate academy, Singapore. This work was supported by Singapore Institute of Manufacturing Technology A*STAR Grant U18‐B‐017SU SIMT/18‐410006. M.E.W. would like to acknowledge the support of the Australian Research Council via Discovery Project Grant (DP170103704).en_US
item.fulltextNo Fulltext-
Appears in Collections:MAE Journal Articles

Page view(s)

Updated on Oct 17, 2021

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.