Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151118
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dc.contributor.authorMoloudi, Rezaen_US
dc.contributor.authorOh, Steveen_US
dc.contributor.authorYang, Chunen_US
dc.contributor.authorTeo, Kim Lengen_US
dc.contributor.authorLam, Alan Tin-Lunen_US
dc.contributor.authorWarkiani, Majid Ebrahimien_US
dc.contributor.authorNaing, May Winen_US
dc.date.accessioned2021-07-29T10:35:06Z-
dc.date.available2021-07-29T10:35:06Z-
dc.date.issued2019-
dc.identifier.citationMoloudi, R., Oh, S., Yang, C., Teo, K. L., Lam, A. T., Warkiani, M. E. & Naing, M. W. (2019). Scaled-up inertial microfluidics : retention system for microcarrier-based suspension cultures. Biotechnology Journal, 14(5), 1800674-. https://dx.doi.org/10.1002/biot.201800674en_US
dc.identifier.issn1860-6768en_US
dc.identifier.urihttps://hdl.handle.net/10356/151118-
dc.description.abstractRecently, particle concentration and filtration using inertial microfluidics have drawn attention as an alternative to membrane and centrifugal technologies for industrial applications, where the target particle size varies between 1 µm and 500 µm. Inevitably, the bigger particle size (>50 µm) mandates scaling up the channel cross-section or hydraulic diameter (DH > 0.5 mm). The Dean-coupled inertial focusing dynamics in spiral microchannels is studied broadly; however, the impacts of secondary flow on particle migration in a scaled-up spiral channel is not fully elucidated. The mechanism of particle focusing inside scaled-up rectangular and trapezoidal spiral channels (i.e., 5-10× bigger than conventional microchannels) with an aim to develop a continuous and clog-free microfiltration system for bioprocessing is studied in detail. Herein, a unique focusing based on inflection point without the aid of sheath flow is reported. This new focusing mechanism, observed in the scaled-up channels, out-performs the conventional focusing scenarios in the previously reported trapezoidal and rectangular channels. Finally, as a proof-of-concept, the utility of this device is showcased for the first time as a retention system for a cell-microcarrier (MC) suspension culture.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.language.isoenen_US
dc.relationU18‐B‐017SU SIMT/18‐410006en_US
dc.relation.ispartofBiotechnology Journalen_US
dc.rights© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleScaled-up inertial microfluidics : retention system for microcarrier-based suspension culturesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.researchSingapore Institute of Manufacturing Technologyen_US
dc.identifier.doi10.1002/biot.201800674-
dc.identifier.pmid30791214-
dc.identifier.scopus2-s2.0-85065832755-
dc.identifier.issue5en_US
dc.identifier.volume14en_US
dc.identifier.spage1800674en_US
dc.subject.keywordsInertial Microfluidicsen_US
dc.subject.keywordsMesenchymal Stem Cellsen_US
dc.description.acknowledgementR.M. would like to thank the SINGA scholarship sponsorship by A*STAR graduate academy, Singapore. This work was supported by Singapore Institute of Manufacturing Technology A*STAR Grant U18‐B‐017SU SIMT/18‐410006. M.E.W. would like to acknowledge the support of the Australian Research Council via Discovery Project Grant (DP170103704).en_US
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