Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151212
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dc.contributor.authorNur Farhanah Roslien_US
dc.contributor.authorFojtů, Michaelaen_US
dc.contributor.authorFisher, Adrian C.en_US
dc.contributor.authorPumera, Martinen_US
dc.date.accessioned2021-07-02T03:08:27Z-
dc.date.available2021-07-02T03:08:27Z-
dc.date.issued2019-
dc.identifier.citationNur Farhanah Rosli, Fojtů, M., Fisher, A. C. & Pumera, M. (2019). Graphene oxide nanoplatelets potentiate anticancer effect of cisplatin in human lung cancer cells. Langmuir, 35(8), 3176-3182. https://dx.doi.org/10.1021/acs.langmuir.8b03086en_US
dc.identifier.issn0743-7463en_US
dc.identifier.other0000-0001-5846-2951-
dc.identifier.urihttps://hdl.handle.net/10356/151212-
dc.description.abstractGraphene oxide (GO) has been widely explored by many in drug delivery strategies and toxicity assays. The toxicity of graphene oxide depends on the size of the sheets. Smaller sheets show lower toxicity, a quality which is essential for utilization in biomedical applications. However, despite vast research on GO, anticancer properties and drug carrier capabilities of graphene oxide nanoplatelets have yet to be fully explored. Herein, we have uniquely prepared graphene oxide nanoplatelets (GONPs) from well-defined stacked graphite nanofibers (SGNF) with a base of 50 × 50 nm2 for toxicity and drug potentiation studies when coadministered with the chemotherapeutic drug cisplatin (CP) in human lung cancer cells, A549 cells. Results obtained from our studies have found that not only were GONPs able to act as drug carriers, but they can also significantly potentiate anticancer effect of CP in A549 cells.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationSERC A1783c0005en_US
dc.relation.ispartofLangmuiren_US
dc.rights© 2019 American Chemical Society. All rights reserved.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleGraphene oxide nanoplatelets potentiate anticancer effect of cisplatin in human lung cancer cellsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1021/acs.langmuir.8b03086-
dc.identifier.pmid30741550-
dc.identifier.scopus2-s2.0-85061976127-
dc.identifier.issue8en_US
dc.identifier.volume35en_US
dc.identifier.spage3176en_US
dc.identifier.epage3182en_US
dc.subject.keywordsOxidesen_US
dc.subject.keywordsTwo Dimensional Materialsen_US
dc.description.acknowledgementThis work was supported by the project Advanced Functional Nanorobots (reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). Authors thank the A*Star grant (No. SERC A1783c0005), Singapore. This research is supported by the National Research Foundation, Prime Minister’s Office, Singapore under its CREATE programme. This work was supported by Grant Agency of the Czech Republic (GACR - 18-24089S).en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
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