Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151214
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dc.contributor.authorYoon, Bo Kyeongen_US
dc.contributor.authorJackman, Joshua A.en_US
dc.contributor.authorPark, Soohyunen_US
dc.contributor.authorMokrzecka, Nataliaen_US
dc.contributor.authorCho, Nam-Joonen_US
dc.date.accessioned2021-07-02T03:09:18Z-
dc.date.available2021-07-02T03:09:18Z-
dc.date.issued2019-
dc.identifier.citationYoon, B. K., Jackman, J. A., Park, S., Mokrzecka, N. & Cho, N. (2019). Characterizing the membrane-disruptive behavior of dodecylglycerol using supported lipid bilayers. Langmuir, 35(9), 3568-3575. https://dx.doi.org/10.1021/acs.langmuir.9b00244en_US
dc.identifier.issn0743-7463en_US
dc.identifier.other0000-0002-1800-8102-
dc.identifier.other0000-0002-8692-8955-
dc.identifier.urihttps://hdl.handle.net/10356/151214-
dc.description.abstractMonoglycerides are esterified adducts of fatty acid and glycerol molecules that disrupt phospholipid membranes, leading to a wide range of biological functions such as antimicrobial activity. Among monoglycerides, glycerol monolaurate (GML) exhibits particularly high antimicrobial activity, although enzymatic hydrolysis of its ester group can diminish potency. Consequently, there have been efforts to identify more chemically stable versions of GML, most notably its alkylglycerol ether equivalent called dodecylglycerol (DDG). However, despite high structural similarity, biological studies indicate that DDG and GML are not functionally equivalent and it has been speculated that the two compounds might have different interaction profiles with phospholipid membranes. To address this outstanding question, herein, we employed supported lipid bilayer (SLB) platforms to experimentally characterize the interactions of DDG with phospholipid membranes. Quartz crystal microbalance-dissipation experiments identified that DDG causes concentration-dependent membrane morphological changes in SLBs and the overall extent of membrane remodeling events was greater than that caused by GML. In addition, time-lapsed fluorescence microscopy imaging experiments revealed that DDG causes extensive membrane tubulation that is distinct from how GML induces membrane budding. We discuss how differences in the head group properties of DDG and GML contribute to distinct membrane interaction profiles, offering insight into how the molecular design of DDG not only improves chemical stability but also enhances membrane-disruptive activity.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationNRF2015NRF-POC001-019en_US
dc.relationSRG/14028en_US
dc.relation.ispartofLangmuiren_US
dc.rights© 2019 American Chemical Society. All rights reserved.en_US
dc.subjectEngineering::Materialsen_US
dc.titleCharacterizing the membrane-disruptive behavior of dodecylglycerol using supported lipid bilayersen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1021/acs.langmuir.9b00244-
dc.identifier.pmid30720282-
dc.identifier.scopus2-s2.0-85062399444-
dc.identifier.issue9en_US
dc.identifier.volume35en_US
dc.identifier.spage3568en_US
dc.identifier.epage3575en_US
dc.subject.keywordsMorphologyen_US
dc.subject.keywordsLipidsen_US
dc.description.acknowledgementThis work was supported by a National Research Foundation Proof-of-Concept Grant (NRF2015NRF-POC001-019), an A*STAR-NTU-NHG Skin Research Grant (SRG/14028), and the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) that is funded by the Ministry of Science, ICT, and Future Planning (2016M3D1A1024098).en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
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