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dc.contributor.authorLee, Jonathan H.en_US
dc.contributor.authorLuo, Xiaomanen_US
dc.contributor.authorRen, Xiafeien_US
dc.contributor.authorTan, Tuan Chunen_US
dc.contributor.authorSmith, Raymond A. A.en_US
dc.contributor.authorSwaminathan, Kunchithapadamen_US
dc.contributor.authorSekar, Sakthivelen_US
dc.contributor.authorBhakoo, Kishoreen_US
dc.contributor.authorNurcombe, Victoren_US
dc.contributor.authorHui, James H.en_US
dc.contributor.authorCool, Simon M.en_US
dc.identifier.citationLee, J. H., Luo, X., Ren, X., Tan, T. C., Smith, R. A. A., Swaminathan, K., Sekar, S., Bhakoo, K., Nurcombe, V., Hui, J. H. & Cool, S. M. (2019). A heparan sulfate device for the regeneration of osteochondral defects. Tissue Engineering, Part A, 25(5-6), 352-363.
dc.description.abstractThe regeneration of cartilage is challenging due to its low metabolic rate and avascular nature. An effective treatment for osteochondral defects remains a clinical challenge. Glycosaminoglycans such as heparan sulfate (HS) bind and enhance the activity of prochondrogenic growth factors and thus hold potential for targeted tissue regeneration without the requirement for exogenous growth factors. In this study, we examine the use of a cell- and growth factor-free HS-based technique for osteochondral repair in a rabbit model. The binding affinity between HS and several reparative proteins (TGF-β1, BMP-2, FGF-2, PDGF-BB, and VEGF₁₆₅) was studied using surface plasmon resonance. Next, an HS-impregnated gel was implanted in a large osteochondral defect in the femoral trochlea of 19 New Zealand white rabbits to study the efficacy of the treatment. Over a 12-week period, HS showed significantly enhanced subchondral bone regeneration compared with a hydrogel control. Treatment with HS also resulted in an increased presence of hyaline cartilage in the chondral region. The use of HS in osteochondral defects appears to improve both subchondral and chondral tissue repair. Our data suggest that this effect is mediated by the ability of HS to promote endogenous growth factors.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.relation.ispartofTissue Engineering, Part Aen_US
dc.rights© 2019 Mary Ann Liebert, Inc., publishers. All rights reserved.en_US
dc.titleA heparan sulfate device for the regeneration of osteochondral defectsen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.organizationInstitute of Medical Biology, A*STARen_US
dc.subject.keywordsOsteochondral Defecten_US
dc.subject.keywordsHeparan Sulfateen_US
dc.description.acknowledgementThe authors acknowledge the funding support of Singapore's Agency for Science, Technology and Research (A*STAR) and Institute of Medical Biology (IMB). Funding was also provided by the National Medical Research Council (NMRC), Singapore (No. CIRG16may052).en_US
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