Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151241
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dc.contributor.authorYang, Chengbinen_US
dc.contributor.authorChan, Kok Kenen_US
dc.contributor.authorXu, Gaixiaen_US
dc.contributor.authorYin, Ming-jieen_US
dc.contributor.authorLin, Guimiaoen_US
dc.contributor.authorWang, Xiaomeien_US
dc.contributor.authorLin, Wei-Jenen_US
dc.contributor.authorMuhammad Danang Birowosutoen_US
dc.contributor.authorZeng, Shuwenen_US
dc.contributor.authorOgi, Takashien_US
dc.contributor.authorOkuyama, Kikuoen_US
dc.contributor.authorPermatasari, Fitri Auliaen_US
dc.contributor.authorIskandar, Ferryen_US
dc.contributor.authorChen, Chih-Kuangen_US
dc.contributor.authorYong, Ken-Tyeen_US
dc.date.accessioned2021-07-26T09:23:02Z-
dc.date.available2021-07-26T09:23:02Z-
dc.date.issued2019-
dc.identifier.citationYang, C., Chan, K. K., Xu, G., Yin, M., Lin, G., Wang, X., Lin, W., Muhammad Danang Birowosuto, Zeng, S., Ogi, T., Okuyama, K., Permatasari, F. A., Iskandar, F., Chen, C. & Yong, K. (2019). Biodegradable polymer-coated multifunctional graphene quantum dots for light-triggered synergetic therapy of pancreatic cancer. ACS Applied Materials and Interfaces, 11(3), 2768-2781. https://dx.doi.org/10.1021/acsami.8b16168en_US
dc.identifier.issn1944-8244en_US
dc.identifier.other0000-0001-9672-7412-
dc.identifier.other0000-0002-0592-4427-
dc.identifier.other0000-0002-9997-6841-
dc.identifier.other0000-0003-2188-7213-
dc.identifier.other0000-0003-3982-857X-
dc.identifier.other0000-0002-7896-2424-
dc.identifier.other0000-0001-7936-2941-
dc.identifier.urihttps://hdl.handle.net/10356/151241-
dc.description.abstractIn this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a nanocarrier was utilized to co-load doxorubicin (DOX) and small interfering ribonucleic acid (siRNA), resulting in the formation of GQD/DOX/BCPV/siRNA nanocomplexes. The resulting nanocomplexes have demonstrated high stability in physiologically mimicking media, excellent K-ras downregulation activity, and effective bioactivity inhibition for MiaPaCa-2 cells. More importantly, laser light was used to generate heat for the nanocomplexes via the photothermal effect to damage the cells, which was further employed to trigger the release of payloads from the nanocomplexes. Such triggered release function greatly enhanced the anticancer activity of the nanocomplexes. Preliminary colony formation study also suggested that GQD/DOX/BCPV/siRNA nanocomplexes are qualified carrier candidates in subsequent in vivo tests.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relationMOE2010-T2-2-010en_US
dc.relationM4020020.040 ARC2/11en_US
dc.relationM4061202.040en_US
dc.relation11235100003en_US
dc.relationNEWRI SF20140901en_US
dc.relation.ispartofACS Applied Materials and Interfacesen_US
dc.rights© 2018 American Chemical Society. All rights reserved.en_US
dc.subjectEngineering::Electrical and electronic engineeringen_US
dc.titleBiodegradable polymer-coated multifunctional graphene quantum dots for light-triggered synergetic therapy of pancreatic canceren_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US
dc.contributor.researchCNRS International NTU THALES Research Alliancesen_US
dc.identifier.doi10.1021/acsami.8b16168-
dc.identifier.pmid30589254-
dc.identifier.scopus2-s2.0-85060059076-
dc.identifier.issue3en_US
dc.identifier.volume11en_US
dc.identifier.spage2768en_US
dc.identifier.epage2781en_US
dc.subject.keywordsGraphene Quantum Dotsen_US
dc.subject.keywordsBiodegradable Charged Polyester Vectoren_US
dc.description.acknowledgementThis work was supported by the Singapore Ministry of Education (Grants Tier 2 MOE2010-T2-2-010 (M4020020.040 ARC2/11) the NTU-NHG Innovation Collaboration Grant (M4061202.040), the NTU-ASTAR Silicon Technologies, Centre of Excellence, under the program grant no. 11235100003, the NEWRI seed funding (grant no. NEWRI SF20140901) the research grants (nos. MOST 106-2221-E-224-058-; MOST 107-2221-E-224-059-MY2) supported by the Ministry of Science and Technology of Taiwan, and the grants from the National Natural Science Foundation of China (NSFC) (81400591).en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
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