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Title: Biodegradable polymer-coated multifunctional graphene quantum dots for light-triggered synergetic therapy of pancreatic cancer
Authors: Yang, Chengbin
Chan, Kok Ken
Xu, Gaixia
Yin, Ming-jie
Lin, Guimiao
Wang, Xiaomei
Lin, Wei-Jen
Muhammad Danang Birowosuto
Zeng, Shuwen
Ogi, Takashi
Okuyama, Kikuo
Permatasari, Fitri Aulia
Iskandar, Ferry
Chen, Chih-Kuang
Yong, Ken-Tye
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2019
Source: Yang, C., Chan, K. K., Xu, G., Yin, M., Lin, G., Wang, X., Lin, W., Muhammad Danang Birowosuto, Zeng, S., Ogi, T., Okuyama, K., Permatasari, F. A., Iskandar, F., Chen, C. & Yong, K. (2019). Biodegradable polymer-coated multifunctional graphene quantum dots for light-triggered synergetic therapy of pancreatic cancer. ACS Applied Materials and Interfaces, 11(3), 2768-2781.
Project: MOE2010-T2-2-010
M4020020.040 ARC2/11
NEWRI SF20140901
Journal: ACS Applied Materials and Interfaces 
Abstract: In this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a nanocarrier was utilized to co-load doxorubicin (DOX) and small interfering ribonucleic acid (siRNA), resulting in the formation of GQD/DOX/BCPV/siRNA nanocomplexes. The resulting nanocomplexes have demonstrated high stability in physiologically mimicking media, excellent K-ras downregulation activity, and effective bioactivity inhibition for MiaPaCa-2 cells. More importantly, laser light was used to generate heat for the nanocomplexes via the photothermal effect to damage the cells, which was further employed to trigger the release of payloads from the nanocomplexes. Such triggered release function greatly enhanced the anticancer activity of the nanocomplexes. Preliminary colony formation study also suggested that GQD/DOX/BCPV/siRNA nanocomplexes are qualified carrier candidates in subsequent in vivo tests.
ISSN: 1944-8244
DOI: 10.1021/acsami.8b16168
Rights: © 2018 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:EEE Journal Articles

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