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|Title:||Impact of timing between insulin administration and meal consumption on glycemic fluctuation and outcomes in hospitalized patients with type 2 diabetes||Authors:||Lim, Shu Fang
Chew, Daniel Ek Kwang
Lee, Joyce Yu-Chia
|Keywords:||Science::Medicine||Issue Date:||2018||Source:||Lim, S. F., Jong, M., Chew, D. E. K. & Lee, J. Y. (2018). Impact of timing between insulin administration and meal consumption on glycemic fluctuation and outcomes in hospitalized patients with type 2 diabetes. Journal of Pharmacy Practice, 33(4), 449-456. https://dx.doi.org/10.1177/0897190018818908||Journal:||Journal of Pharmacy Practice||Abstract:||Background: The effect of time interval from insulin injection to meal consumption (“insulin-meal”) on glycemic fluctuation and outcomes is not well understood. Objective: This study aims to investigate the impact of coordinated versus mismatched insulin-meal administration on glycemic fluctuation and outcomes among hospitalized patients with type 2 diabetes (T2D).Methods: Hospitalized patients with T2D who received at least 1 dose of insulin as part of sliding scale regimen were included. Data such as capillary blood glucose values and insulin-meal time intervals were collected.Results: A total of 215 patients with 840 insulin-meal encounters were eligible for the study. Compared to the insulin-meal mismatch group (n = 206), the coordinated insulin-meal administration group (n = 9) had lower mean glycemic fluctuation (6.5 [2.6] mmol/L vs 5.6 [2.5] mmol/L or 117  mg/dL vs 100  mg/dL). Encounters with the insulin-meal time interval of 30 to 45 minutes (n = 172) were associated with the lowest percentage of severe hyperglycemia occurrences (13%) as compared to encounters with time interval of 0 to 29 minutes (n = 280, 15%) and more than 45 minutes (n = 246, 16%). Conclusion: Coordinated insulin-meal administration was associated with lower glycemic fluctuation among hospitalized patients with T2D.||URI:||https://hdl.handle.net/10356/151302||ISSN:||0897-1900||DOI:||10.1177/0897190018818908||Rights:||© The Author(s). All rights reserved.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
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