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dc.contributor.authorXie, Zhongxien_US
dc.contributor.authorCai, Xuechaoen_US
dc.contributor.authorSun, Chunqiangen_US
dc.contributor.authorLiang, Shuangen_US
dc.contributor.authorShao, Shuaien_US
dc.contributor.authorHuang, Shanshanen_US
dc.contributor.authorCheng, Ziyongen_US
dc.contributor.authorPang, Maolinen_US
dc.contributor.authorXing, Bengangen_US
dc.contributor.authorAl-Kheraif, Abdulaziz Abdullahen_US
dc.contributor.authorLin, Junen_US
dc.identifier.citationXie, Z., Cai, X., Sun, C., Liang, S., Shao, S., Huang, S., Cheng, Z., Pang, M., Xing, B., Al-Kheraif, A. A. & Lin, J. (2018). O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy. Chemistry of Materials, 31(2), 483-490.
dc.description.abstractTumor therapy is facing great challenges in improving drug efficiency while reducing side effects. Herein, a novel multifunctional nanodrug carrier UC@mSiO2-RB@ZIF-O2-DOX-PEGFA (URODF) that combines oxygen (O2)-enhanced photodynamic therapy (PDT) with pH-responsive chemotherapy is presented. Eight hundred eight nanometer NIR light-irradiated NaYF4:Yb/Er@NaYbF4:Nd@NaGdF4 nanoparticles (UC) were employed as both upconversion/magnetic resonance imaging matrix and motivator for photosensitizer in PDT with deep penetration depth. Mesoporous silica shell (mSiO2) was used as the carrier for photosensitizer Rose Bengal (RB). Zeolitic imidazolate framework-90 (ZIF-90) was coated outside of mSiO2 as O2 reservoir to quickly release O2 in tumor microenvironment and alleviate tumor hypoxia for enhanced PDT. Doxorubicin (DOX) and NH2-poly(ethylene glycol) modified folic acid (PEGFA) were covalently conjugated on the surface of nanoparticles for synergetic therapy. The drug-loading capacity reaches 5.6 and 6.0% for RB and DOX, respectively. In vitro and in vivo experiments demonstrate great therapeutic effect of URODF. This work presents for the first time a multifunctional nanodrug carrier that combines upconversion nanoparticles with metal–organic framework structure for O2-loaded combination therapy, which might open a promising way of enhancing tumor therapeutic efficacy.en_US
dc.relation.ispartofChemistry of Materialsen_US
dc.rights© 2018 American Chemical Society. All rights reserved.en_US
dc.titleO2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.subject.keywordsCancer Therapyen_US
dc.description.acknowledgementThis project is financially supported by the National Natural Science Foundation of China (NSFC 51720105015, 51332008, 51828202, 51628201, 51772288, 51572257, and 21728101), Chinese Academy of Sciences (YZDY-SSWJSC018), CAS-Croucher Funding Scheme for Joint Laboratories (CAS18204), and the Science and Technology Development Plan of Jilin Province (20170101187JC and 20170414003GH), Jiangmen Innovative Research Team Program (2017), and Major program of basic research and applied research of Guangdong Province (2017KZDXM083), and the Distinguished Scientist Fellowship Program of King Saud University as well as the Deanship of Scientific Research at King Saud University for funding this work through research group (RG-1939-038).en_US
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