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Title: O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy
Authors: Xie, Zhongxi
Cai, Xuechao
Sun, Chunqiang
Liang, Shuang
Shao, Shuai
Huang, Shanshan
Cheng, Ziyong
Pang, Maolin
Xing, Bengang
Al-Kheraif, Abdulaziz Abdullah
Lin, Jun
Keywords: Science::Chemistry
Issue Date: 2018
Source: Xie, Z., Cai, X., Sun, C., Liang, S., Shao, S., Huang, S., Cheng, Z., Pang, M., Xing, B., Al-Kheraif, A. A. & Lin, J. (2018). O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy. Chemistry of Materials, 31(2), 483-490.
Journal: Chemistry of Materials
Abstract: Tumor therapy is facing great challenges in improving drug efficiency while reducing side effects. Herein, a novel multifunctional nanodrug carrier UC@mSiO2-RB@ZIF-O2-DOX-PEGFA (URODF) that combines oxygen (O2)-enhanced photodynamic therapy (PDT) with pH-responsive chemotherapy is presented. Eight hundred eight nanometer NIR light-irradiated NaYF4:Yb/Er@NaYbF4:Nd@NaGdF4 nanoparticles (UC) were employed as both upconversion/magnetic resonance imaging matrix and motivator for photosensitizer in PDT with deep penetration depth. Mesoporous silica shell (mSiO2) was used as the carrier for photosensitizer Rose Bengal (RB). Zeolitic imidazolate framework-90 (ZIF-90) was coated outside of mSiO2 as O2 reservoir to quickly release O2 in tumor microenvironment and alleviate tumor hypoxia for enhanced PDT. Doxorubicin (DOX) and NH2-poly(ethylene glycol) modified folic acid (PEGFA) were covalently conjugated on the surface of nanoparticles for synergetic therapy. The drug-loading capacity reaches 5.6 and 6.0% for RB and DOX, respectively. In vitro and in vivo experiments demonstrate great therapeutic effect of URODF. This work presents for the first time a multifunctional nanodrug carrier that combines upconversion nanoparticles with metal–organic framework structure for O2-loaded combination therapy, which might open a promising way of enhancing tumor therapeutic efficacy.
ISSN: 0897-4756
DOI: 10.1021/acs.chemmater.8b04321
Rights: © 2018 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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