Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151331
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dc.contributor.authorCh'ng, Jun-Hongen_US
dc.contributor.authorChong, Kelvin Kian Longen_US
dc.contributor.authorLam, Ling Ningen_US
dc.contributor.authorWong, Jun Jieen_US
dc.contributor.authorKline, Kimberly A.en_US
dc.date.accessioned2021-06-22T06:14:22Z-
dc.date.available2021-06-22T06:14:22Z-
dc.date.issued2019-
dc.identifier.citationCh'ng, J., Chong, K. K. L., Lam, L. N., Wong, J. J. & Kline, K. A. (2019). Biofilm-associated infection by enterococci. Nature Reviews Microbiology, 17(2), 82-94. https://dx.doi.org/10.1038/s41579-018-0107-zen_US
dc.identifier.issn1740-1526en_US
dc.identifier.other0000-0002-5472-3074-
dc.identifier.urihttps://hdl.handle.net/10356/151331-
dc.description.abstractEnterococci are ubiquitous members of the human gut microbiota and frequent causes of biofilm-associated opportunistic infections. Enterococci cause 25% of all catheter-associated urinary tract infections, are frequently isolated in wounds and are increasingly found in infective endocarditis, and all of these infections are associated with biofilms. Enterococcal biofilms are intrinsically tolerant to antimicrobials and thus are a serious impediment for treating infections. In this Review, we describe the spatiotemporal development of enterococcal biofilms and the factors that promote or inhibit biofilm formation. We discuss how the environment, including the host and other co-colonizing microorganisms, affects biofilm development. Finally, we provide an overview of current and future interventions to limit enterococcal biofilm-associated infections. Overall, enterococcal biofilms remain a pressing clinical problem, and there is an urgent need to better understand their development and persistence and to identify novel treatments.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationMOE2014-T2-2-124en_US
dc.relation.ispartofNature Reviews Microbiologyen_US
dc.rights© 2018 Springer Nature Limited. All rights reserved.en_US
dc.subjectEngineering::Environmental engineeringen_US
dc.titleBiofilm-associated infection by enterococcien_US
dc.typeJournal Articleen
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.researchSingapore Centre for Environmental Life Sciences and Engineeringen_US
dc.contributor.researchNTU Institute for Health Technologiesen_US
dc.identifier.doi10.1038/s41579-018-0107-z-
dc.identifier.pmid30337708-
dc.identifier.scopus2-s2.0-85055356351-
dc.identifier.issue2en_US
dc.identifier.volume17en_US
dc.identifier.spage82en_US
dc.identifier.epage94en_US
dc.subject.keywordsAntimicrobial Resistanceen_US
dc.subject.keywordsBacterial Pathogenesisen_US
dc.description.acknowledgementWork in the Kline laboratory related to this article is supported by the Ministry of Education Singapore under its Research Centre of Excellence Program and by the Ministry of Education Singapore under its Tier 2 programme (MOE2014-T2-2-124) and the National Institutes of Health (NIH; 1 R21 AI126023-01).en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
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