Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/151372
Title: | Antimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extract | Authors: | Ramalingam, Raghavendra Dhand, Chetna Leung, Chak Ming Ong, Seow Theng Annamalai, Sathesh Kumar Mohammed Kamruddin Verma, Navin Kumar Ramakrishna, Seeram Lakshminarayanan, Rajamani Arunachalam, Kantha Deivi |
Keywords: | Science::Medicine | Issue Date: | 2019 | Source: | Ramalingam, R., Dhand, C., Leung, C. M., Ong, S. T., Annamalai, S. K., Mohammed Kamruddin, Verma, N. K., Ramakrishna, S., Lakshminarayanan, R. & Arunachalam, K. D. (2019). Antimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extract. Materials Science and Engineering: C, 98, 503-514. https://dx.doi.org/10.1016/j.msec.2018.12.135 | Project: | NMRC/TCR/008-SERI/2013 NMRC/CBRG/0048/ 2013 R1181/83/2014 L0412290 SAI-L0494003 2015-T1-001-082 IAF-PP H17/01/a0/0K9 |
Journal: | Materials Science and Engineering: C | Abstract: | Wound care management presents one of the substantial and tenacious challenges to the healthcare systems worldwide. Microbial colonization and subsequent biofilm formation after injury have garnered much attention, as there is an appreciable correlation between biofilms formation and delayed healing in chronic wounds. Nanotechnology has emerged as a potential platform for the management of treating acute and chronic wounds. This study presents the utility of electrospun nanofiber mats containing a natural extract (Gymnema sylvestre) that averts biofilm formation but supports human dermal fibroblasts (hDFs) attachment. The scaffolds exhibited good wettability, enhanced mechanical properties and contact mediated inhibition of Gram-positive and Gram-negative bacteria. MTS viability assay and confocal imaging further confirmed that the natural extract loaded mats remained non-cytotoxic for hDFs. Overall these findings evidenced the suitability of the Gymnema sylvestre (GS) functionalized electrospun poly-ε-caprolactone (PCL) nanofibers, as an effective wound dressing with broad spectrum anti-bacterial properties. | URI: | https://hdl.handle.net/10356/151372 | ISSN: | 0928-4931 | DOI: | 10.1016/j.msec.2018.12.135 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Organisations: | Anti-Infectives Research Group, Singapore Eye Research Institute The Academia |
Rights: | © 2018 Published by Elsevier B.V. All rights reserved. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
SCOPUSTM
Citations
10
57
Updated on Mar 24, 2024
Web of ScienceTM
Citations
10
42
Updated on Oct 29, 2023
Page view(s)
282
Updated on Mar 28, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.