Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151372
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dc.contributor.authorRamalingam, Raghavendraen_US
dc.contributor.authorDhand, Chetnaen_US
dc.contributor.authorLeung, Chak Mingen_US
dc.contributor.authorOng, Seow Thengen_US
dc.contributor.authorAnnamalai, Sathesh Kumaren_US
dc.contributor.authorMohammed Kamruddinen_US
dc.contributor.authorVerma, Navin Kumaren_US
dc.contributor.authorRamakrishna, Seeramen_US
dc.contributor.authorLakshminarayanan, Rajamanien_US
dc.contributor.authorArunachalam, Kantha Deivien_US
dc.date.accessioned2021-07-09T02:49:07Z-
dc.date.available2021-07-09T02:49:07Z-
dc.date.issued2019-
dc.identifier.citationRamalingam, R., Dhand, C., Leung, C. M., Ong, S. T., Annamalai, S. K., Mohammed Kamruddin, Verma, N. K., Ramakrishna, S., Lakshminarayanan, R. & Arunachalam, K. D. (2019). Antimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extract. Materials Science and Engineering: C, 98, 503-514. https://dx.doi.org/10.1016/j.msec.2018.12.135en_US
dc.identifier.issn0928-4931en_US
dc.identifier.other0000-0002-5940-6633-
dc.identifier.other0000-0001-8214-5315-
dc.identifier.other0000-0001-5510-1333-
dc.identifier.urihttps://hdl.handle.net/10356/151372-
dc.description.abstractWound care management presents one of the substantial and tenacious challenges to the healthcare systems worldwide. Microbial colonization and subsequent biofilm formation after injury have garnered much attention, as there is an appreciable correlation between biofilms formation and delayed healing in chronic wounds. Nanotechnology has emerged as a potential platform for the management of treating acute and chronic wounds. This study presents the utility of electrospun nanofiber mats containing a natural extract (Gymnema sylvestre) that averts biofilm formation but supports human dermal fibroblasts (hDFs) attachment. The scaffolds exhibited good wettability, enhanced mechanical properties and contact mediated inhibition of Gram-positive and Gram-negative bacteria. MTS viability assay and confocal imaging further confirmed that the natural extract loaded mats remained non-cytotoxic for hDFs. Overall these findings evidenced the suitability of the Gymnema sylvestre (GS) functionalized electrospun poly-ε-caprolactone (PCL) nanofibers, as an effective wound dressing with broad spectrum anti-bacterial properties.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationNMRC/TCR/008-SERI/2013en_US
dc.relationNMRC/CBRG/0048/ 2013en_US
dc.relationR1181/83/2014en_US
dc.relationL0412290en_US
dc.relationSAI-L0494003en_US
dc.relation2015-T1-001-082en_US
dc.relationIAF-PP H17/01/a0/0K9en_US
dc.relation.ispartofMaterials Science and Engineering: Cen_US
dc.rights© 2018 Published by Elsevier B.V. All rights reserved.en_US
dc.subjectScience::Medicineen_US
dc.titleAntimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extracten_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.organizationAnti-Infectives Research Group, Singapore Eye Research Instituteen_US
dc.contributor.organizationThe Academiaen_US
dc.identifier.doi10.1016/j.msec.2018.12.135-
dc.identifier.pmid30813052-
dc.identifier.scopus2-s2.0-85059684148-
dc.identifier.volume98en_US
dc.identifier.spage503en_US
dc.identifier.epage514en_US
dc.subject.keywordsElectrospinningen_US
dc.subject.keywordsGymnema Sylvestre Leaf Extractsen_US
dc.description.acknowledgementThe authors gratefully acknowledge the financial support from UGC-DAE Consortium for Scientific Research (CSR-KN/CRS-70/2015- 16/811) Kalpakkam, Tamilnadu, India, Translational and Clinical Research Flagship Program of the Singapore National Research Foundation (NMRC/TCR/008-SERI/2013), administered by the National Medical Research Council of the Singapore Ministry of Health. This work was supported by Co-operative Basic Research Grant from the Singapore National Medical Research Council (NMRC/CBRG/0048/ 2013) and SNEC Ophthalmic Technologies Incubator Program grant (Project no. R1181/83/2014) awarded to RL. NKV acknowledges funding support from Lee Kong Chian School of Medicine, Nanyang Technological University Singapore Start-Up Grant (L0412290), Strategic Academic Initiative Grant (SAI-L0494003), the Ministry of Education - Singapore under its Singapore Ministry of Education Academic (AcRF) Research Fund Tier I (2015-T1-001-082) and Industry Alignment Fund Pre-Positioning Grant (IAF-PP H17/01/a0/0K9).en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Collections:LKCMedicine Journal Articles

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