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Title: Antimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extract
Authors: Ramalingam, Raghavendra
Dhand, Chetna
Leung, Chak Ming
Ong, Seow Theng
Annamalai, Sathesh Kumar
Mohammed Kamruddin
Verma, Navin Kumar
Ramakrishna, Seeram
Lakshminarayanan, Rajamani
Arunachalam, Kantha Deivi
Keywords: Science::Medicine
Issue Date: 2019
Source: Ramalingam, R., Dhand, C., Leung, C. M., Ong, S. T., Annamalai, S. K., Mohammed Kamruddin, Verma, N. K., Ramakrishna, S., Lakshminarayanan, R. & Arunachalam, K. D. (2019). Antimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extract. Materials Science and Engineering: C, 98, 503-514.
Project: NMRC/TCR/008-SERI/2013
NMRC/CBRG/0048/ 2013
IAF-PP H17/01/a0/0K9
Journal: Materials Science and Engineering: C 
Abstract: Wound care management presents one of the substantial and tenacious challenges to the healthcare systems worldwide. Microbial colonization and subsequent biofilm formation after injury have garnered much attention, as there is an appreciable correlation between biofilms formation and delayed healing in chronic wounds. Nanotechnology has emerged as a potential platform for the management of treating acute and chronic wounds. This study presents the utility of electrospun nanofiber mats containing a natural extract (Gymnema sylvestre) that averts biofilm formation but supports human dermal fibroblasts (hDFs) attachment. The scaffolds exhibited good wettability, enhanced mechanical properties and contact mediated inhibition of Gram-positive and Gram-negative bacteria. MTS viability assay and confocal imaging further confirmed that the natural extract loaded mats remained non-cytotoxic for hDFs. Overall these findings evidenced the suitability of the Gymnema sylvestre (GS) functionalized electrospun poly-ε-caprolactone (PCL) nanofibers, as an effective wound dressing with broad spectrum anti-bacterial properties.
ISSN: 0928-4931
DOI: 10.1016/j.msec.2018.12.135
Rights: © 2018 Published by Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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