Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151376
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dc.contributor.authorNakayama, Masanarien_US
dc.contributor.authorLim, Wei Qien_US
dc.contributor.authorKajiyama, Satoshien_US
dc.contributor.authorKumamoto, Akihitoen_US
dc.contributor.authorIkuhara, Yuichien_US
dc.contributor.authorKato, Takashien_US
dc.contributor.authorZhao, Yanlien_US
dc.date.accessioned2021-07-23T06:03:17Z-
dc.date.available2021-07-23T06:03:17Z-
dc.date.issued2019-
dc.identifier.citationNakayama, M., Lim, W. Q., Kajiyama, S., Kumamoto, A., Ikuhara, Y., Kato, T. & Zhao, Y. (2019). Liquid-crystalline hydroxyapatite/polymer nanorod hybrids : potential bioplatform for photodynamic therapy and cellular scaffolds. ACS Applied Materials and Interfaces, 11(19), 17759-17765. https://dx.doi.org/10.1021/acsami.9b02485en_US
dc.identifier.issn1944-8244en_US
dc.identifier.other0000-0001-7023-3801-
dc.identifier.other0000-0002-2200-7524-
dc.identifier.other0000-0002-9730-3045-
dc.identifier.other0000-0003-3886-005X-
dc.identifier.other0000-0002-0571-0883-
dc.identifier.other0000-0002-9231-8360-
dc.identifier.urihttps://hdl.handle.net/10356/151376-
dc.description.abstractRecently, we found that self-organization of hydroxyapatite (HAp) with poly(acrylic acid) (PAA) leads to the formation of liquid-crystalline (LC) nanorod hybrids that form aligned films and show stimuli-responsive properties. Here, we demonstrate that these biocompatible HAp/PAA hybrid nanorods represent a platform technology as drug nanocarriers for photodynamic cancer therapy and as bioscaffolds for the control of cellular alignment and growth. To use hybrid nanorods as a drug nanocarrier, we introduced methylene blue (MB), a typical photosensitizer for photodynamic therapy, into the PAA nanolayer covering the surface of the HAp nanocrystals through electrostatic interactions. The stable MB-loaded HAp/PAA hybrid nanorods efficiently produced singlet oxygen from MB upon light irradiation and showed remarkable photodynamic therapeutic effects in cancer cells. Moreover, taking advantage of the mechanically responsive LC alignment properties of the HAp/PAA hybrid nanorods, macroscopically oriented bioscaffolds were prepared through a spin-coating process. The cells cultured on the oriented scaffolds showed cellular alignment and elongation along the oriented direction of the hybrid nanorods. The HAp/PAA hybrid nanorods demonstrate potential in drug delivery and tissue engineering. These unique LC HAp/PAA hybrid nanorods have significant potential as a platform for the development of various types of biomaterial.en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationNRF-NRFI2018-03en_US
dc.relation.ispartofACS Applied Materials and Interfacesen_US
dc.rights© 2019 American Chemical Society. All rights reserved.en_US
dc.subjectScience::Chemistryen_US
dc.titleLiquid-crystalline hydroxyapatite/polymer nanorod hybrids : potential bioplatform for photodynamic therapy and cellular scaffoldsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1021/acsami.9b02485-
dc.identifier.pmid31010284-
dc.identifier.scopus2-s2.0-85065773146-
dc.identifier.issue19en_US
dc.identifier.volume11en_US
dc.identifier.spage17759en_US
dc.identifier.epage17765en_US
dc.subject.keywordsPhotodynamic Therapy Drug Nanocarrieren_US
dc.subject.keywordsDrug Nanocarrieren_US
dc.description.acknowledgementThis study was partly supported by JSPS KAKENHI Grant Numbers JP15H02179 and JP17J09259. M.N. is grateful for financial support from a Japan Society for the Promotion of Science (JSPS) Research Fellowship for Young Scientists and the JSPS Program for Leading Graduate Schools (MERIT). The authors are grateful to Dr. S.Y. for performing the ζ-potential measurements. TEM observations were conducted at the Advanced Characterization Nanotechnology Platform at the University of Tokyo, which is supported by the “Nanotechnology Platform” of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. This work was also partially supported by the Singapore National Research Foundation Investigatorship (No. NRF-NRFI2018-03).en_US
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