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Title: Liquid-crystalline hydroxyapatite/polymer nanorod hybrids : potential bioplatform for photodynamic therapy and cellular scaffolds
Authors: Nakayama, Masanari
Lim, Wei Qi
Kajiyama, Satoshi
Kumamoto, Akihito
Ikuhara, Yuichi
Kato, Takashi
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2019
Source: Nakayama, M., Lim, W. Q., Kajiyama, S., Kumamoto, A., Ikuhara, Y., Kato, T. & Zhao, Y. (2019). Liquid-crystalline hydroxyapatite/polymer nanorod hybrids : potential bioplatform for photodynamic therapy and cellular scaffolds. ACS Applied Materials and Interfaces, 11(19), 17759-17765.
Project: NRF-NRFI2018-03
Journal: ACS Applied Materials and Interfaces 
Abstract: Recently, we found that self-organization of hydroxyapatite (HAp) with poly(acrylic acid) (PAA) leads to the formation of liquid-crystalline (LC) nanorod hybrids that form aligned films and show stimuli-responsive properties. Here, we demonstrate that these biocompatible HAp/PAA hybrid nanorods represent a platform technology as drug nanocarriers for photodynamic cancer therapy and as bioscaffolds for the control of cellular alignment and growth. To use hybrid nanorods as a drug nanocarrier, we introduced methylene blue (MB), a typical photosensitizer for photodynamic therapy, into the PAA nanolayer covering the surface of the HAp nanocrystals through electrostatic interactions. The stable MB-loaded HAp/PAA hybrid nanorods efficiently produced singlet oxygen from MB upon light irradiation and showed remarkable photodynamic therapeutic effects in cancer cells. Moreover, taking advantage of the mechanically responsive LC alignment properties of the HAp/PAA hybrid nanorods, macroscopically oriented bioscaffolds were prepared through a spin-coating process. The cells cultured on the oriented scaffolds showed cellular alignment and elongation along the oriented direction of the hybrid nanorods. The HAp/PAA hybrid nanorods demonstrate potential in drug delivery and tissue engineering. These unique LC HAp/PAA hybrid nanorods have significant potential as a platform for the development of various types of biomaterial.
ISSN: 1944-8244
DOI: 10.1021/acsami.9b02485
Rights: © 2019 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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