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Title: OXTR moderates adverse childhood experiences on depressive symptoms among incarcerated males
Authors: Zhang, Jieting
Yang, Cuimei
Leng, Junhui
Liu, Jinting
Gong, Pingyuan
Esposito, Gianluca
Keywords: Social sciences::Psychology
Issue Date: 2021
Source: Zhang, J., Yang, C., Leng, J., Liu, J., Gong, P. & Esposito, G. (2021). OXTR moderates adverse childhood experiences on depressive symptoms among incarcerated males. Journal of Psychiatric Research, 140, 221-227.
Journal: Journal of Psychiatric Research
Abstract: Objectives: This study examined the moderation of an oxytocin receptor (OXTR) gene in the link between childhood adversity and depressive symptoms among incarcerated males. Methods: Questionnaires about adverse childhood experiences and depressive symptoms, as well as genomic DNA from blood were collected among 608 incarcerated males (Mage = 32.4 years, SD = 9.41, 18–74 years). Moderation analysis was applied to examine the interaction between adverse childhood experiences (including abuse, neglect, and household dysfunction) and the OXTR polymorphisms (rs2254298, rs53576) in predicting depressive symptoms. Results: Incarcerated males had relatively higher prevalence of childhood adversity (70.2%) and depressive symptoms (49.8%). Higher childhood adversity was associated with increased depressive symptoms, and the effect was more pronounced in the GG homozygotes of OXTR rs2254298 (b = 0.406, p < .001), as compared with the AA/AG carriers (b = 0.236, p < .001). By contrast, the OXTR rs53576 did not interact with childhood adversity in predicting depressive symptoms. Conclusions: Chinese incarcerated males with the GG genotype of OXTR rs2254298 have higher vulnerability in the effect of childhood adversity on depressive symptoms.
ISSN: 0022-3956
DOI: 10.1016/j.jpsychires.2021.05.043
Rights: © 2021 Elsevier. All rights reserved. This paper was published in Journal of Psychiatric Research and is made available with permission of Elsevier.
Fulltext Permission: embargo_20220831
Fulltext Availability: With Fulltext
Appears in Collections:SSS Journal Articles

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