Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151443
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dc.contributor.authorZhou, Chengen_US
dc.contributor.authorChia, Geraldine Wan Nien_US
dc.contributor.authorHo, James Chin Shingen_US
dc.contributor.authorMoreland, Alex S.en_US
dc.contributor.authorSeviour, Thomasen_US
dc.contributor.authorLiedberg, Boen_US
dc.contributor.authorParikh, Atul N.en_US
dc.contributor.authorKjelleberg, Staffanen_US
dc.contributor.authorHinks, Jamieen_US
dc.contributor.authorBazan, Guillermo C.en_US
dc.date.accessioned2021-07-13T00:40:02Z-
dc.date.available2021-07-13T00:40:02Z-
dc.date.issued2019-
dc.identifier.citationZhou, C., Chia, G. W. N., Ho, J. C. S., Moreland, A. S., Seviour, T., Liedberg, B., Parikh, A. N., Kjelleberg, S., Hinks, J. & Bazan, G. C. (2019). A chain-elongated oligophenylenevinylene electrolyte increases microbial membrane stability. Advanced Materials, 31(18), 1808021-. https://dx.doi.org/10.1002/adma.201808021en_US
dc.identifier.issn0935-9648en_US
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dc.identifier.other0000-0002-2537-0310-
dc.identifier.urihttps://hdl.handle.net/10356/151443-
dc.description.abstractA novel conjugated oligoelectrolyte (COE) material, named S6, is designed to have a lipid-bilayer stabilizing topology afforded by an extended oligophenylenevinylene backbone. S6 intercalates biological membranes acting as a hydrophobic support for glycerophospholipid acyl chains. Indeed, Escherichia coli treated with S6 exhibits a twofold improvement in butanol tolerance, a relevant feature to achieve within the general context of modifying microorganisms used in biofuel production. Filamentous growth, a morphological stress response to butanol toxicity in E. coli, is observed in untreated cells after incubation with 0.9% butanol (v/v), but is mitigated by S6 treatment. Real-time fluorescence imaging using giant unilamellar vesicles reveals the extent to which S6 counters membrane instability. Moreover, S6 also reduces butanol-induced lipopolysaccharide release from the outer membrane to further maintain cell integrity. These findings highlight a deliberate effort in the molecular design of a chain-elongated COE to stabilize microbial membranes against environmental challenges.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relationM4081984.120en_US
dc.relationM4360005en_US
dc.relation.ispartofAdvanced Materialsen_US
dc.rights© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleA chain-elongated oligophenylenevinylene electrolyte increases microbial membrane stabilityen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.researchSingapore Centre for Environmental Life Sciences and Engineering (SCELSE)en_US
dc.identifier.doi10.1002/adma.201808021-
dc.identifier.pmid30908801-
dc.identifier.scopus2-s2.0-85063400316-
dc.identifier.issue18en_US
dc.identifier.volume31en_US
dc.identifier.spage1808021en_US
dc.subject.keywordsBiofuelsen_US
dc.subject.keywordsButanol Toleranceen_US
dc.description.acknowledgementC.Z. and G.W.N.C. contributed equally to this work. G.C.B. thanks the NTU start up grant M4081984.120. Work at SCELSE was supported by the Singapore Ministry of Education through grant M4360005. Work at UCSB was supported by the Institute for Collaborative Biotechnologies through grant W911NF-09-D-0001.en_US
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