Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151443
Title: A chain-elongated oligophenylenevinylene electrolyte increases microbial membrane stability
Authors: Zhou, Cheng
Chia, Geraldine Wan Ni
Ho, James Chin Shing
Moreland, Alex S.
Seviour, Thomas
Liedberg, Bo
Parikh, Atul N.
Kjelleberg, Staffan
Hinks, Jamie
Bazan, Guillermo C.
Keywords: Engineering::Chemical engineering
Issue Date: 2019
Source: Zhou, C., Chia, G. W. N., Ho, J. C. S., Moreland, A. S., Seviour, T., Liedberg, B., Parikh, A. N., Kjelleberg, S., Hinks, J. & Bazan, G. C. (2019). A chain-elongated oligophenylenevinylene electrolyte increases microbial membrane stability. Advanced Materials, 31(18), 1808021-. https://dx.doi.org/10.1002/adma.201808021
Project: M4081984.120
M4360005 
Journal: Advanced Materials
Abstract: A novel conjugated oligoelectrolyte (COE) material, named S6, is designed to have a lipid-bilayer stabilizing topology afforded by an extended oligophenylenevinylene backbone. S6 intercalates biological membranes acting as a hydrophobic support for glycerophospholipid acyl chains. Indeed, Escherichia coli treated with S6 exhibits a twofold improvement in butanol tolerance, a relevant feature to achieve within the general context of modifying microorganisms used in biofuel production. Filamentous growth, a morphological stress response to butanol toxicity in E. coli, is observed in untreated cells after incubation with 0.9% butanol (v/v), but is mitigated by S6 treatment. Real-time fluorescence imaging using giant unilamellar vesicles reveals the extent to which S6 counters membrane instability. Moreover, S6 also reduces butanol-induced lipopolysaccharide release from the outer membrane to further maintain cell integrity. These findings highlight a deliberate effort in the molecular design of a chain-elongated COE to stabilize microbial membranes against environmental challenges.
URI: https://hdl.handle.net/10356/151443
ISSN: 0935-9648
DOI: 10.1002/adma.201808021
Rights: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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