Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/151449
Title: | Minimally invasive electroceutical catheter for endoluminal defect sealing | Authors: | Singh, Manisha Varela, Claudia E. Whyte, William Horvath, Markus A. Tan, Nigel C. S. Ong, Chee Bing Liang, Patric Schermerhorn, Marc L. Roche, Ellen T. Steele, Terry W. J. |
Keywords: | Engineering::Bioengineering Engineering::Materials |
Issue Date: | 2021 | Source: | Singh, M., Varela, C. E., Whyte, W., Horvath, M. A., Tan, N. C. S., Ong, C. B., Liang, P., Schermerhorn, M. L., Roche, E. T. & Steele, T. W. J. (2021). Minimally invasive electroceutical catheter for endoluminal defect sealing. Science Advances, 7(14). https://dx.doi.org/10.1126/sciadv.abf6855 | Journal: | Science Advances | Abstract: | Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally-invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally-invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in-vivo and ex-vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 mm in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudoaneurysms/fistulae to bioelectrodes towards electrophysiological mapping. | URI: | https://hdl.handle.net/10356/151449 | ISSN: | 2375-2548 | DOI: | 10.1126/sciadv.abf6855 | Schools: | School of Materials Science and Engineering | Rights: | © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | MSE Journal Articles |
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Minimally invasive electroceutical catheter for endoluminal defect sealing.pdf | 12.56 MB | Adobe PDF | ![]() View/Open |
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