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Title: Minimally invasive electroceutical catheter for endoluminal defect sealing
Authors: Singh, Manisha
Varela, Claudia E.
Whyte, William
Horvath, Markus A.
Tan, Nigel C. S.
Ong, Chee Bing
Liang, Patric
Schermerhorn, Marc L.
Roche, Ellen T.
Steele, Terry W. J.
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Singh, M., Varela, C. E., Whyte, W., Horvath, M. A., Tan, N. C. S., Ong, C. B., Liang, P., Schermerhorn, M. L., Roche, E. T. & Steele, T. W. J. (2021). Minimally invasive electroceutical catheter for endoluminal defect sealing. Science Advances, 7(14).
Journal: Science Advances 
Abstract: Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally-invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally-invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in-vivo and ex-vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 mm in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudoaneurysms/fistulae to bioelectrodes towards electrophysiological mapping.
ISSN: 2375-2548
DOI: 10.1126/sciadv.abf6855
Rights: © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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