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Title: On-chip optical detection of viruses : a review
Authors: Shi, Yuzhi
Li, Zhenyu
Liu, Patricia Yang
Nguyen, Binh Thi Thanh
Wu, Wenshuai
Zhao, Qianbin
Chin, Lip Ket
Yap, Peng Huat
Zhou, Xiaohong
Zhao, Hongwei
Yu, Dan
Tsai, Din Ping
Liu, Ai Qun
Keywords: Science
Issue Date: 2021
Source: Shi, Y., Li, Z., Liu, P. Y., Nguyen, B. T. T., Wu, W., Zhao, Q., Chin, L. K., Yap, P. H., Zhou, X., Zhao, H., Yu, D., Tsai, D. P. & Liu, A. Q. (2021). On-chip optical detection of viruses : a review. Advanced Photonics Research, 2(4), 2000150-.
Project: NRFCRP13-2014-01
Journal: Advanced Photonics Research
Abstract: The current outbreak of the coronavirus disease-19 (COVID-19) pandemic worldwide has caused millions of fatalities and imposed a severe impact on our daily lives. Thus, the global healthcare system urgently calls for rapid, affordable, and reliable detection toolkits. Although the gold-standard nucleic acid amplification tests have been widely accepted and utilized, they are time-consuming and labor-intensive, which exceedingly hinder the mass detection in low-income populations, especially in developing countries. Recently, due to the blooming development of photonics, various optical chips have been developed to detect single viruses with the advantages of fast, label-free, affordable, and point of care deployment. Herein, optical approaches especially in three perspectives, e.g., flow-free optical methods, optofluidics, and surface-modification-assisted approaches, are summarized. The future development of on-chip optical-detection methods in the wave of emerging new ideas in nanophotonics is also briefly discussed.
ISSN: 2699-9293
DOI: 10.1002/adpr.202000150
Schools: School of Electrical and Electronic Engineering 
Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: Centre for Bio Devices and Signal Analysis (VALENS) 
Rights: © 2021 The Authors. Advanced Photonics Research published by Wiley- VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

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