Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/151641
Full metadata record
DC FieldValueLanguage
dc.contributor.authorZhu, Wenzhenen_US
dc.contributor.authorIqbal, Jabeden_US
dc.contributor.authorWang, Dong-Anen_US
dc.date.accessioned2021-07-09T07:17:26Z-
dc.date.available2021-07-09T07:17:26Z-
dc.date.issued2019-
dc.identifier.citationZhu, W., Iqbal, J. & Wang, D. (2019). A DOPA-functionalized chondroitin sulfate-based adhesive hydrogel as a promising multi-functional bioadhesive. Journal of Materials Chemistry B, 7(10), 1741-1752. https://dx.doi.org/10.1039/C8TB01990Hen_US
dc.identifier.issn2050-7518en_US
dc.identifier.urihttps://hdl.handle.net/10356/151641-
dc.description.abstractGreat progress has been achieved on the study of hydrogels, which were presented for the first time in 1960 by Otto Wichterle and Drahoslav Lím. The two crucial properties of hydrogels, namely high water content and biocompatibility, have made hydrogels ideal compositions in the development of bioadhesives in recent years. Chondroitin sulfate (CS), a sulfated glycosaminoglycan (GAG), is distributed throughout animal bodies, including cartilage and the extracellular matrix (ECM), and it has been widely utilized in the dietary supplement and pharmaceutical industries. Besides, CS has been reported to have excellent pain-relief and anti-inflammation properties. Some studies have even reported CS's wound healing promoting ability. In this study, taking advantage of CS's excellent physical and chemical properties, DOPA groups were functionalized onto CS backbones. After that, the potential of the newly established CS-DOPA (CSD) hydrogel to work as a bioadhesive in multiple internal medical conditions was evaluated through in vitro and in vivo means. The outcomes of the in vivo assessments demonstrated CSD's promising potential to be further commercialized into an adhesive hydrogel product, and to be utilized in diverse clinical medications in the future.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationMOE2016-T2-1-138 (S)en_US
dc.relation.ispartofJournal of Materials Chemistry Ben_US
dc.rights© 2019 The Royal Society of Chemistry. All rights reserved.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleA DOPA-functionalized chondroitin sulfate-based adhesive hydrogel as a promising multi-functional bioadhesiveen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1039/C8TB01990H-
dc.identifier.issue10en_US
dc.identifier.volume7en_US
dc.identifier.spage1741en_US
dc.identifier.epage1752en_US
dc.subject.keywordsLinked Tissue Adhesiveen_US
dc.subject.keywordsRat Mastectomyen_US
dc.description.acknowledgementThe work was financially supported by Grant AcRF Tier 2 Academic Research Fund (MOE2016-T2-1-138 (S) to Wang Dong-An), Ministry of Education (MOE), Singapore.en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Collections:SCBE Journal Articles

SCOPUSTM   
Citations 10

25
Updated on Jul 9, 2022

PublonsTM
Citations 10

19
Updated on Jul 6, 2022

Page view(s)

140
Updated on Aug 16, 2022

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.