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Title: Cobalt-catalyzed regio- and diastereoselective formal [3 + 2] cycloaddition between cyclopropanols and allenes
Authors: Yang, Junfeng
Sun, Qiao
Yoshikai, Naohiko
Keywords: Science::Chemistry
Issue Date: 2019
Source: Yang, J., Sun, Q. & Yoshikai, N. (2019). Cobalt-catalyzed regio- and diastereoselective formal [3 + 2] cycloaddition between cyclopropanols and allenes. ACS Catalysis, 9(3), 1973-1978.
Project: MOE2016-T2-2-043
Journal: ACS Catalysis
Abstract: A cobalt-diphosphine catalyst has been found to promote a formal [3 + 2] cycloaddition reaction between a cyclopropanol and an allene via cyclopropanol ring opening, which affords a 3-alkylidenecyclopentanol derivative with high regio- and diastereoselectivities. The reaction tolerates monosubstituted, 1,1-disubstituted, and 1,3-disubstituted allenes and various functional groups. The reaction is proposed to proceed through carbometalation of the allene with a cobalt homoenolate followed by intramolecular carbonyl allylation of the resulting allylcobalt species.
ISSN: 2155-5435
DOI: 10.1021/acscatal.8b05114
Rights: © 2019 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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