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Title: Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults
Authors: Tranæs, Kaare
Ding, Cherlyn
Chooi, Yu Chung
Chan, Zhiling
Choo, John
Leow, Melvin Khee-Shing
Magkos, Faidon
Keywords: Science::Medicine
Issue Date: 2021
Source: Tranæs, K., Ding, C., Chooi, Y. C., Chan, Z., Choo, J., Leow, M. K. & Magkos, F. (2021). Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults. Frontiers in Nutrition, 8, 651199-.
Project: BMSI/16-07803C-R20H 
Journal: Frontiers in Nutrition 
Abstract: Insulin resistance in obesity coincides with abnormalities in lipid profile and lipoprotein subclass distribution and size even before abnormalities in glucose homeostasis manifest. We aimed to assess this relationship in the absence of obesity. Insulin sensitivity (3-h intravenous glucose tolerance test and minimal modeling) and lipoprotein particle concentrations and sizes (proton nuclear magnetic resonance spectroscopy) were evaluated in 15 insulin-resistant and 15 insulin-sensitive lean Asians of Chinese descent with normal glucose tolerance, matched on age, sex, and body mass index. Despite a ~50% lower insulin sensitivity index (Si) in insulin-resistant than in insulin-sensitive subjects, which was accompanied by significantly greater acute insulin response to glucose (AIRg) and fasting insulin concentration but not different fasting glucose concentration, there were no significant differences between groups in the blood lipid profile (p ≥ 0.44) or the lipoprotein subclass concentrations (p ≥ 0.30) and particle sizes (p ≥ 0.43). We conclude that, contrary to observations in subjects with obesity, insulin resistance is not accompanied by unfavorable changes in the plasma lipid profile and lipoprotein particle concentrations and sizes in lean Asians with normal glucose tolerance. Therefore, insulin resistance at the level of glucose metabolism is mechanistically or temporally dissociated from lipid and lipoprotein metabolism.
ISSN: 2296-861X
DOI: 10.3389/fnut.2021.651199
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Singapore Institute for Clinical Sciences, A*STAR
Rights: © 2021 Tranæs, Ding, Chooi, Chan, Choo, Leow and Magkos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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