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Title: Invalidation of the transcriptional modulator of lipid metabolism PPARβ/δ in T cells prevents age-related alteration of body composition and loss of endurance capacity
Authors: Rousseau, Anne-Sophie
Murdaca, Joseph
Le Menn, Gwenaëlle
Sibille, Brigitte
Wahli, Walter
Le Garf, Sébastien
Chinetti, Giulia
Neels, Jaap G.
Mothe-Satney, Isabelle
Keywords: Science::Medicine
Issue Date: 2021
Source: Rousseau, A., Murdaca, J., Le Menn, G., Sibille, B., Wahli, W., Le Garf, S., Chinetti, G., Neels, J. G. & Mothe-Satney, I. (2021). Invalidation of the transcriptional modulator of lipid metabolism PPARβ/δ in T cells prevents age-related alteration of body composition and loss of endurance capacity. Frontiers in Physiology, 12, 587753-.
Journal: Frontiers in Physiology 
Abstract: Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4⁺ T cells by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate in secondary lymphoid organs and are involved in impairment of skeletal muscle (SKM) regeneration and mass maintenance. In this study, we showed that a deletion of a FAO modulator, peroxisome proliferator-activated receptor beta/delta (PPARβ/δ), specifically in T cells (KO-T PPARβ/δ), increased the number of CD4⁺ T cells at day 2 following a cardiotoxin-induced SKM regeneration. Older KO-T PPARβ/δ mice maintained a Tregs prevalence in lymph nodes similar to young mice. Surprisingly, KO-T PPARβ/δ mice were protected from the effects of age on lean and fat mass and endurance capacity. Our results lead us to propose an original potential role of T cell metabolism in the effects of aging on the maintenance of body composition and endurance capacity.
ISSN: 1664-042X
DOI: 10.3389/fphys.2021.587753
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2021 Rousseau, Murdaca, Le Menn, Sibille, Wahli, Le Garf, Chinetti, Neels and Mothe-Satney. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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