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dc.contributor.authorLow, Dorrain Yanwenen_US
dc.contributor.authorHejndorf, Sophiaen_US
dc.contributor.authorTharmabalan, Rachel Thomasen_US
dc.contributor.authorPoppema, Sibrandesen_US
dc.contributor.authorPettersson, Svenen_US
dc.identifier.citationLow, D. Y., Hejndorf, S., Tharmabalan, R. T., Poppema, S. & Pettersson, S. (2021). Regional diets targeting gut microbial dynamics to support prolonged healthspan. Frontiers in Microbiology, 12, 659465-.
dc.description.abstractIn the last 150 years, we have seen a significant increase in average life expectancy, associated with a shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often the largest risk factor, highlights the need for contemporary societies to improve healthy ageing for their growing silver generations. As ageing is an inevitable, non-reversing and highly individualised process, we need to better understand how non-genetic factors like diet choices and commensal gut microbes can modulate the biology of ageing. In this review, we discuss how geographical and ethnic variations influence habitual dietary patterns, nutrient structure, and gut microbial profiles with potential impact on the human healthspan. Several gut microbial genera have been associated with healthy elderly populations but are highly variable across populations. It seems unlikely that a universal pro-longevity gut microbiome exists. Rather, the optimal microbiome appears to be conditional on the microbial functionality acting on regional- and ethnicity-specific trends driven by cultural food context. We also highlight dietary and microbial factors that have been observed to elicit individual and clustered biological responses. Finally, we identify next generation avenues to modify otherwise fixed host functions and the individual ageing trajectory by manipulating the malleable gut microbiome with regionally adapted, personalised food intervention regimens targeted at prolonging human healthspan.en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.relation.ispartofFrontiers in Microbiologyen_US
dc.rights© 2021 Low, Hejndorf, Tharmabalan, Poppema and Pettersson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.titleRegional diets targeting gut microbial dynamics to support prolonged healthspanen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.description.versionPublished versionen_US
dc.subject.keywordsGut Microbiomeen_US
dc.subject.keywordsGut Microbiotaen_US
dc.description.acknowledgementDL received the support of Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, through the award of the Presidential Postdoctoral Fellowship (Grant No. 001991-00001).en_US
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