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Title: Shifting the gears of metabolic plasticity to drive cell state transitions in cancer
Authors: Wu, Zhengwei
Lee, Yi Fei
Yeo, Xun Hui
Loo, Ser Yue
Tam, Wai Leong
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Wu, Z., Lee, Y. F., Yeo, X. H., Loo, S. Y. & Tam, W. L. (2021). Shifting the gears of metabolic plasticity to drive cell state transitions in cancer. Cancers, 13(6), 1316-.
Project: OFIRG17may061
Journal: Cancers
Abstract: Cancer metabolism is a hallmark of cancer. Metabolic plasticity defines the ability of cancer cells to reprogram a plethora of metabolic pathways to meet unique energetic needs during the various steps of disease progression. Cell state transitions are phenotypic adaptations which confer distinct advantages that help cancer cells overcome progression hurdles, that include tumor initiation, expansive growth, resistance to therapy, metastasis, colonization, and relapse. It is increasingly appreciated that cancer cells need to appropriately reprogram their cellular metabolism in a timely manner to support the changes associated with new phenotypic cell states. We discuss metabolic alterations that may be adopted by cancer cells in relation to the maintenance of cancer stemness, activation of the epithelial–mesenchymal transition program for facilitating metastasis, and the acquisition of drug resistance. While such metabolic plasticity is harnessed by cancer cells for survival, their dependence and addiction towards certain metabolic pathways also present therapeutic opportunities that may be exploited.
ISSN: 2072-6694
DOI: 10.3390/cancers13061316
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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