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Title: Early detection of alzheimer's disease using polar harmonic transforms and optimized wavelet neural network
Authors: Urooj, Shabana
Singh, Satya P.
Malibari, Areej
Alrowais, Fadwa
Kalathil, Shaeen
Keywords: Science::Medicine
Issue Date: 2021
Source: Urooj, S., Singh, S. P., Malibari, A., Alrowais, F. & Kalathil, S. (2021). Early detection of alzheimer's disease using polar harmonic transforms and optimized wavelet neural network. Applied Sciences, 11(4), 1574-.
Journal: Applied Sciences
Abstract: Effective and accurate diagnosis of Alzheimer’s disease (AD), as well as early-stage detection, has gained more and more attention in recent years. For AD classification, we propose a new hybrid method for early detection of Alzheimer’s disease (AD) using Polar Harmonic Transforms (PHT) and Self-adaptive Differential Evolution Wavelet Neural Network (SaDE-WNN). The orthogonal moments are used for feature extraction from the grey matter tissues of structural Magnetic Resonance Imaging (MRI) data. Irrelevant features are removed by the feature selection process through evaluating the in-class and among-class variance. In recent years, WNNs have gained attention in classification tasks; however, they suffer from the problem of initial parameter tuning, parameter setting. We proposed a WNN with the self-adaptation technique for controlling the Differential Evolution (DE) parameters, i.e., the mutation scale factor (F) and the cross-over rate (CR). Experimental results on the Alzheimer’s disease Neuroimaging Initiative (ADNI) database indicate that the proposed method yields the best overall classification results between AD and mild cognitive impairment (MCI) (93.7% accuracy, 86.0% sensitivity, 98.0% specificity, and 0.97 area under the curve (AUC)), MCI and healthy control (HC) (92.9% accuracy, 95.2% sensitivity, 88.9% specificity, and 0.98 AUC), and AD and HC (94.4% accuracy, 88.7% sensitivity, 98.9% specificity and 0.99 AUC).
ISSN: 2076-3417
DOI: 10.3390/app11041574
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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