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Title: Cationic liposomes enable shape control in surfactant-free synthesis of biocompatible gold nanorods
Authors: Gudlur, Sushanth
Goyal, Garima
Pradhan, Arpan
Ho, James Chin Shing
Srivastava, Rohit
Liedberg, Bo
Keywords: Science::Chemistry::Inorganic chemistry::Synthesis
Science::Chemistry::Inorganic chemistry::Metals
Issue Date: 2021
Source: Gudlur, S., Goyal, G., Pradhan, A., Ho, J. C. S., Srivastava, R. & Liedberg, B. (2021). Cationic liposomes enable shape control in surfactant-free synthesis of biocompatible gold nanorods. Chemistry of Materials, 33(12), 4558-4567.
Project: MOE2018-T2-1-025
Journal: Chemistry of Materials
Abstract: Shape-directing agents that promote anisotropic growth are frequently employed in the synthesis of gold nanorods (GNRs), a typical example of which is the surfactant cetyltrimethylammonium bromide (CTAB). Owing to their cytotoxicity, surfactant-passivated GNRs have little use in biological applications unless made biocompatible via additional downstream processing. Reported herein is the first instance of liposome-directed anisotropic growth of GNRs synthesized in the absence of surfactants. The as-synthesized phospholipid-passivated GNRs are readily biocompatible. Among the phospholipids tested, only liposomes prepared from 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (DOEPC) - a cationic transfection agent employed in lipid-mediated gene transfer in vitro - were capable of exerting shape control. By modifying a previously reported photochemical synthesis method, we developed a one-pot, seedless, DOEPC-mediated thermochemical synthesis method that yielded GNRs with an average size of 80-100 nm and an average aspect ratio of ∼3.5 and whose tips shape transformed from smooth to sharp during the course of the synthesis. Further characterization of the as-synthesized phospholipid-passivated GNRs confirmed its stability, excellent biocompatibility, photothermal transduction ability, and application in plasmonic photothermal therapy which was validated via GNR-mediated photothermal ablation of cancer cells in vitro, thus making this route of synthesis attractive for biological applications.
ISSN: 1520-5002
DOI: 10.1021/acs.chemmater.1c00973
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemistry of Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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