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Title: PhosIDP : a web tool to visualize the location of phosphorylation sites in disordered regions
Authors: Nicolaou, Sonia T.
Hebditch, Max
Jonathan, Owen J.
Verma, Chandra Shekhar
Warwicker, Jim
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Nicolaou, S. T., Hebditch, M., Jonathan, O. J., Verma, C. S. & Warwicker, J. (2021). PhosIDP : a web tool to visualize the location of phosphorylation sites in disordered regions. Scientific Reports, 11(1), 9930-.
Project: H17/01/a0/010 
Journal: Scientific Reports 
Abstract: Charge is a key determinant of intrinsically disordered protein (IDP) and intrinsically disordered region (IDR) properties. IDPs and IDRs are enriched in sites of phosphorylation, which alters charge. Visualizing the degree to which phosphorylation modulates the charge profile of a sequence would assist in the functional interpretation of IDPs and IDRs. PhosIDP is a web tool that shows variation of charge and fold propensity upon phosphorylation. In combination with the displayed location of protein domains, the information provided by the web tool can lead to functional inferences for the consequences of phosphorylation. IDRs are components of many proteins that form biological condensates. It is shown that IDR charge, and its modulation by phosphorylation, is more tightly controlled for proteins that are essential for condensate formation than for those present in condensates but inessential.
ISSN: 2045-2322
DOI: 10.1038/s41598-021-88992-0
Schools: School of Biological Sciences 
Organisations: Bioinformatics Institute, A*STAR
Rights: © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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