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dc.contributor.authorEro, Ryaen_US
dc.contributor.authorYan, Xin-Fuen_US
dc.contributor.authorGao, Yong-Guien_US
dc.identifier.citationEro, R., Yan, X. & Gao, Y. (2021). Ribosome protection proteins - “new” players in the global arms race with antibiotic-resistant pathogens. International Journal of Molecular Sciences, 22(10), 5356-.
dc.description.abstractBacteria have evolved an array of mechanisms enabling them to resist the inhibitory effect of antibiotics, a significant proportion of which target the ribosome. Indeed, resistance mechanisms have been identified for nearly every antibiotic that is currently used in clinical practice. With the ever-increasing list of multi-drug-resistant pathogens and very few novel antibiotics in the pharmaceutical pipeline, treatable infections are likely to become life-threatening once again. Most of the prevalent resistance mechanisms are well understood and their clinical significance is recognized. In contrast, ribosome protection protein-mediated resistance has flown under the radar for a long time and has been considered a minor factor in the clinical setting. Not until the recent discovery of the ATP-binding cassette family F protein-mediated resistance in an extensive list of human pathogens has the significance of ribosome protection proteins been truly appreciated. Understanding the underlying resistance mechanism has the potential to guide the development of novel therapeutic approaches to evade or overcome the resistance. In this review, we discuss the latest developments regarding ribosome protection proteins focusing on the current antimicrobial arsenal and pharmaceutical pipeline as well as potential implications for the future of fighting bacterial infections in the time of “superbugs.”en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.subjectScience::Biological sciencesen_US
dc.titleRibosome protection proteins - “new” players in the global arms race with antibiotic-resistant pathogensen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.researchNTU Institute of Structural Biologyen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsAntibiotic Resistanceen_US
dc.subject.keywordsRibosome Protectionen_US
dc.description.acknowledgementThis research was funded by Ministry of Education of Singapore Tier I Grant RG108/20 (to Y.-G.G.).en_US
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