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Title: Anti-inflammatory potential of simvastatin loaded nanoliposomes in 2D and 3D foam cell models
Authors: Rakshit, Moumita
Darwitan, Anastasia
Muktabar, Aristo
Das, Prativa
Nguyen, Luong T. H.
Cao, Ye
Vizetto-Duarte, Catarina
Tang, Jinkai
Wong, Yee Shan
Venkatraman, Subbu
Ng, Kee Woei
Keywords: Science::Medicine
Issue Date: 2021
Source: Rakshit, M., Darwitan, A., Muktabar, A., Das, P., Nguyen, L. T. H., Cao, Y., Vizetto-Duarte, C., Tang, J., Wong, Y. S., Venkatraman, S. & Ng, K. W. (2021). Anti-inflammatory potential of simvastatin loaded nanoliposomes in 2D and 3D foam cell models. Nanomedicine: Nanotechnology, Biology and Medicine, 37, 102434-.
Project: 04INS000156C150
Journal: Nanomedicine: Nanotechnology, Biology and Medicine
Abstract: Atherosclerosis is a multifactorial disease triggered and sustained by risk factors such as high cholesterol, high blood pressure and unhealthy lifestyle. Inflammation plays a pivotal role in atherosclerosis pathogenesis. In this study, we developed a simvastatin (STAT) loaded nanoliposomal formulation (LIPOSTAT) which can deliver the drug into atherosclerotic plaque when administered intravenously. This formulation is easily prepared, stable, and biocompatible with minimal burst release for effective drug delivery. 2D and 3D in vitro models were examined towards anti-inflammatory effects of STAT, both free and in combination with liposomes. LIPOSTAT induced greater cholesterol efflux in the 2D foam cells and significantly reduced inflammation in both 2D and 3D models. LIPOSTAT alleviated inflammation by reducing the secretion of early and late phase pro-inflammatory cytokines, monocyte adherence marker, and lipid accumulation cytokines. Additionally, the 3D foam cell spheroid model is a convenient and practical approach in testing various anti-atherosclerotic drugs without the need for human tissue.
ISSN: 1549-9634
DOI: 10.1016/j.nano.2021.102434
Rights: © 2021 Elsevier. All rights reserved. This paper was published in Nanomedicine: Nanotechnology, Biology and Medicine and is made available with permission of Elsevier.
Fulltext Permission: embargo_20221031
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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  Until 2022-10-31
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