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Title: Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope
Authors: Yao, Xinwen
Ke, Mengyuan
Ho, Yijie
Lin, Emily
Wong, Damon Wing Kee
Tan, Bingyao
Schmetterer, Leopold
Chua, Jacqueline
Keywords: Engineering::Chemical engineering
Issue Date: 2021
Source: Yao, X., Ke, M., Ho, Y., Lin, E., Wong, D. W. K., Tan, B., Schmetterer, L. & Chua, J. (2021). Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope. British Journal of Ophthalmology, 105(3), 426-431.
Project: CG/C010A/2017
Journal: British Journal of Ophthalmology
Abstract: Background/ims: To compare the retinal vessel diameter measurements obtained from the swept-source optical coherence tomography angiography (OCTA; Plex Elite 9000, Carl Zeiss Meditec, USA) and adaptive optics ophthalmoscope (AOO; RTX1, Imagine Eyes, France). Methods: Fifteen healthy subjects, 67% women, mean age (SD) 30.87 (6.19) years, were imaged using OCTA and AOO by a single experienced operator on the same day. Each eye was scanned using two OCTA protocols (3×3 mm² and 9×9 mm²) and two to five AOO scans (1.2×1.2 mm²). The OCTA and AOO scans were scaled to the same pixel resolution. Two independent graders measured the vessel diameter at the same location on the region-of-interest in the three coregistered scans. Differences in vessel diameter measurements between the scans were assessed. Results: The inter-rater agreement was excellent for vessel diameter measurement in both OCTA protocols (ICC=0.92) and AOO (ICC=0.98). The measured vessel diameter was widest from the OCTA 3×3 mm² (55.2±16.3 µm), followed by OCTA 9×9 mm² (54.7±14.3 µm) and narrowest by the AOO (50.5±15.6 µm; p<0.001). Measurements obtained from both OCTA protocols were significantly wider than the AOO scan (OCTA 3×3 mm²: mean difference Δ=4.7 µm, p<0.001; OCTA 9×9 mm²: Δ=4.2 µm, p<0.001). For vessels >45 µm, it appeared to be larger in OCTA 3×3 mm² scan than the 9×9 mm² scan (Δ=1.9 µm; p=0.005), while vessels <45 µm appeared smaller in OCTA 3×3 mm² scan (Δ=−1.3 µm; p=0.009) Conclusions: The diameter of retinal vessels measured from OCTA scans were generally wider than that obtained from AOO scans. Different OCTA scan protocols may affect the vessel diameter measurements. This needs to be considered when OCTA measures such as vessel density are calculated.
ISSN: 0007-1161
DOI: 10.1136/bjophthalmol-2020-316111
Rights: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:
Fulltext Permission: open
Fulltext Availability: With Fulltext
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