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Title: The post-acquisition role of immature dentate gyrus granule cells in memory
Authors: Yamaguchi, Takuma
Keywords: Science::Biological sciences
Issue Date: 2021
Publisher: Nanyang Technological University
Source: Yamaguchi, T. (2021). The post-acquisition role of immature dentate gyrus granule cells in memory. Doctoral thesis, Nanyang Technological University, Singapore.
Project: MOE2018-T1-002-053 
NMRC/ OFIRG/0046/2017 
European Research Council Gant 208132 
Human Frontier Science Programme long-term fellowship 
Abstract: Granule cells in the dentate gyrus (DGCs) are continuously produced through adult neurogenesis. The early maturation stage of adult born DGCs (immature DGCs) developing their functional inputs and outputs is important for making their survival-or-death decision which depends on learning opportunities. Although it has been shown that immature DGCs are involved in memory before acquisition, it is unclear whether immature DGCs are involved in memory after acquisition. To investigate a post-acquisition role of immature DGCs in memory, we did genetic ablation of immature DGCs after training of spatial or fear memory tasks, and then examined the effect of ablation in their retrieval tests. Results showed the impairment in single retrieval tests, suggesting that immature DGCs have a post-acquisition role. Further analysis showed the intact retrieval in the initial phase of trial and discontinued learned behavior later, suggesting that they have a post-acquisition role in persistency of learned behavior.
DOI: 10.32657/10356/152344
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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