Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/152400
Title: Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies
Authors: Gupta, Ipshita
Su, Xiaoqian
Jonnalagadda, Umesh Sai
Das, Dhiman
Pramanik, Manojit
Kwan, James J.
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Gupta, I., Su, X., Jonnalagadda, U. S., Das, D., Pramanik, M. & Kwan, J. J. (2021). Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies. Ultrasound in Medicine and Biology, 47(7), 1844-1856. https://dx.doi.org/10.1016/j.ultrasmedbio.2021.02.012
Project: RG144/18 
RG127/19 
NMRC/OFYIRG/0034/2017 
Journal: Ultrasound in Medicine and Biology 
Abstract: Polymer nanoparticles and microparticles have been used primarily for drug delivery. There is now growing interest in further developing polymer-based solid cavitation agents to also enhance ultrasound imaging. We previously reported on a facile method to produce hollow poly(lactic-co-glycolic acid) (PLGA) microparticles with different diameters and degrees of porosity. Here, we investigate the cavitation response from these PLGA microparticles with both therapeutic and diagnostic ultrasound transducers. Interestingly, all formulations exhibited stable cavitation; larger porous and multicavity particles also provided inertial cavitation at elevated acoustic pressure amplitudes. These larger particles also achieved contrast enhancement comparable to that of commercially available ultrasound contrast agents, with a maximum recorded contrast-to-tissue ratio of 28 dB. Therefore, we found that multicavity PLGA microparticles respond to both therapeutic and diagnostic ultrasound and may be applied as a theranostic agent.
URI: https://hdl.handle.net/10356/152400
ISSN: 0301-5629
DOI: 10.1016/j.ultrasmedbio.2021.02.012
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2021 World Federation for Ultrasound in Medicine & Biology. All rights reserved. This paper was published by Elsevier in Ultrasound in Medicine and Biology and is made available with permission of World Federation for Ultrasound in Medicine & Biology.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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