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Title: Nanotechnology facilitated cultured neuronal network and its applications
Authors: Singh, Satnam
Mishra, Sachin
Juha, Song
Pramanik, Manojit
Padmanabhan, Parasuraman
Gulyás, Balázs
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Singh, S., Mishra, S., Juha, S., Pramanik, M., Padmanabhan, P. & Gulyás, B. (2021). Nanotechnology facilitated cultured neuronal network and its applications. International Journal of Molecular Sciences, 22(11), 5552-.
Journal: International Journal of Molecular Sciences 
Abstract: The development of a biomimetic neuronal network from neural cells is a big challenge for researchers. Recent advances in nanotechnology, on the other hand, have enabled unprecedented tools and techniques for guiding and directing neural stem cell proliferation and differentiation in vitro to construct an in vivo-like neuronal network. Nanotechnology allows control over neural stem cells by means of scaffolds that guide neurons to reform synaptic networks in suitable directions in 3D architecture, surface modification/nanopatterning to decide cell fate and stimulate/record signals from neurons to find out the relationships between neuronal circuit connectivity and their pathophysiological functions. Overall, nanotechnology-mediated methods facilitate precise physiochemical controls essential to develop tools appropriate for applications in neuroscience. This review emphasizes the newest applications of nanotechnology for examining central nervous system (CNS) roles and, therefore, provides an insight into how these technologies can be tested in vitro before being used in preclinical and clinical research and their potential role in regenerative medicine and tissue engineering.
ISSN: 1661-6596
DOI: 10.3390/ijms22115552
Schools: School of Chemical and Biomedical Engineering 
Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Karolinska Institute
Research Centres: Cognitive Neuroimaging Centre
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCBE Journal Articles

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