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Title: Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation
Authors: Su, Xiaoqian
Rakshit, Moumita
Das, Prativa
Gupta, Ipshita
Das, Dhiman
Pramanik, Manojit
Ng, Kee Woei
Kwan, James
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Su, X., Rakshit, M., Das, P., Gupta, I., Das, D., Pramanik, M., Ng, K. W. & Kwan, J. (2021). Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation. ACS Applied Materials and Interfaces, 13(21), 24422-24430.
Project: RG144/18 
RG127/ 19 
Journal: ACS Applied Materials and Interfaces 
Abstract: For site-specific diseases such as atherosclerosis, it is desirable to noninvasively and locally deliver therapeutics for extended periods of time. High-intensity focused ultrasound (HIFU) provides targeted drug delivery, yet remains unable to sustain delivery beyond the HIFU treatment time. Furthermore, methods to validate HIFU-enhanced drug delivery remain limited. In this study, we report on HIFU-targeted implantation of degradable drug-loaded sound-sensitive multicavity PLGA microparticles (mcPLGA MPs) as a theranostic agent for the treatment of arterial lesions. Once implanted into the targeted tissue, mcPLGA MPs eluted dexamethasone for several days, thereby reducing inflammatory markers linked to oxidized lipid uptake in a foam cell spheroid model. Furthermore, implanted mcPLGA MPs created hyperechoic regions on diagnostic ultrasound images, and thus noninvasively verified that the target region was treated with the theranostic agents. This novel and innovative multifunctional theranostic platform may serve as a promising candidate for noninvasive imaging and treatment for site-specific diseases such as atherosclerosis.
ISSN: 1944-8244
DOI: 10.1021/acsami.1c01161
Schools: School of Chemical and Biomedical Engineering 
School of Materials Science and Engineering 
Research Centres: Nanyang Environment and Water Research Institute 
Environmental Chemistry and Materials Centre
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
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