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Title: An optical coherence photoacoustic microscopy system using a fiber optic sensor
Authors: Deng, Shiyu
Haindl, Richard
Zhang, Edward
Beard, Paul
Scheuringer, Eva
Sturtzel, Caterine
Li, Qian
Deloria, Abigail J.
Sattmann, Harald
Leitgeb, Rainer A.
Yuan, Yi
Schmetterer, Leopold
Pramanik, Manojit
Distel, Martin
Drexler, Wolfgang
Liu, Mengyang
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Deng, S., Haindl, R., Zhang, E., Beard, P., Scheuringer, E., Sturtzel, C., Li, Q., Deloria, A. J., Sattmann, H., Leitgeb, R. A., Yuan, Y., Schmetterer, L., Pramanik, M., Distel, M., Drexler, W. & Liu, M. (2021). An optical coherence photoacoustic microscopy system using a fiber optic sensor. APL Photonics, 6(9), 096103-.
Journal: APL Photonics
Abstract: In this work, a novel fiber optic sensor based on Fabry-Pérot interferometry is adopted in an optical coherence photoacoustic microscopy (OC-PAM) system to enable high-resolution in vivo imaging. The complete OC-PAM system is characterized using the fiber optic sensor for photoacoustic measurement. After characterization, the performance of the system is evaluated by imaging zebrafish larvae in vivo. With a lateral resolution of 3.4 μm and an axial resolution of 3.7 μm in air, the optical coherence microscopy subsystem visualizes the anatomy of the zebrafish larvae. The photoacoustic microscopy subsystem reveals the vasculature of the zebrafish larvae with a lateral resolution of 1.9 μm and an axial resolution of 37.3 μm. As the two modalities share the same sample arm, we obtain inherently co-registered morphological and vascular images. This OC-PAM system provides comprehensive information on the anatomy and vasculature of the zebrafish larvae. Featuring compactness, broad detection bandwidth, and wide detection angle, the fiber optic sensor enables a large field of view with a static sensor position. We verified the feasibility of the fiber optic sensor for dual-modality in vivo imaging. The OC-PAM system, as a non-invasive imaging method, demonstrates its superiority in the investigation of zebrafish larvae, an animal model with increasing significance in developmental biology and disease research. This technique can also be applied for functional as well as longitudinal studies in the future.
ISSN: 2378-0967
DOI: 10.1063/5.0059351
Rights: © 2021 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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