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|Title:||Keratin-alginate sponges support healing of partial-thickness burns||Authors:||Moay, Zi Kuang
Nguyen, Luong T. H.
Lunny, Declan P.
Kok, Yee Onn
Chong, Si Jack
Chua, Alvin Wen Choong
Ng, Kee Woei
|Keywords:||Engineering::Materials::Biomaterials||Issue Date:||2021||Source:||Moay, Z. K., Nguyen, L. T. H., Hartrianti, P., Lunny, D. P., Leavesley, D., Kok, Y. O., Chong, S. J., Chua, A. W. C., Tee, S. & Ng, K. W. (2021). Keratin-alginate sponges support healing of partial-thickness burns. International Journal of Molecular Sciences, 22(16), 8594-. https://dx.doi.org/10.3390/ijms22168594||Project:||IAF-PP
|Journal:||International Journal of Molecular Sciences||Abstract:||Deep partial-thickness burns damage most of the dermis and can cause severe pain, scarring, and mortality if left untreated. This study serves to evaluate the effectiveness of crosslinked keratin-alginate composite sponges as dermal substitutes for deep partial-thickness burns. Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs. Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges. As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges. Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized. Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.||URI:||https://hdl.handle.net/10356/152703||ISSN:||1661-6596||DOI:||10.3390/ijms22168594||DOI (Related Dataset):||10.21979/N9/MWTEHY||Rights:||© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||MSE Journal Articles|
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Updated on May 15, 2022
Updated on May 15, 2022
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