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Title: Bacterial cellulose adhesive composites for oral cavity applications
Authors: Singh, Juhi
Tan, Nigel Chew Shun
Mahadevaswamy, Usha Rani
Chanchareonsook, Nattharee
Steele, Terry W. J.
Lim, Sierin
Keywords: Engineering::Chemical engineering
Issue Date: 2021
Source: Singh, J., Tan, N. C. S., Mahadevaswamy, U. R., Chanchareonsook, N., Steele, T. W. J. & Lim, S. (2021). Bacterial cellulose adhesive composites for oral cavity applications. Carbohydrate Polymers, 274, 118403-.
Project: RG17/18 (S)
H19/01/a0/ 0II9
Journal: Carbohydrate Polymers
Abstract: Topical approaches to oral diseases require frequent dosing due to limited wound retention times. A mucoadhesive drug delivery platform is proposed for oral wound sites with soft tissue adhesion capability of up to 7 days. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives are combined to yield flexible film platform for interfacing soft tissues in dynamic, wet environments. Structure-activity relationships evaluate UV dose and hydration state with respect to adhesive strength on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging from 7-17 kPa and duration exceeding 48 hours in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5-5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity.
ISSN: 0144-8617
DOI: 10.1016/j.carbpol.2021.118403
Rights: © 2021 Elsevier Ltd. All rights reserved. This paper was published in Carbohydrate Polymers and is made available with permission of Elsevier Ltd.
Fulltext Permission: embargo_20221122
Fulltext Availability: With Fulltext
Appears in Collections:IGS Journal Articles
MSE Journal Articles
SCBE Journal Articles

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