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Title: Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria
Authors: Kingston, Hugh W. F.
Ghose, Aniruddha
Rungpradubvong, Voravut
Satitthummanid, Sudarat
Herdman, M. Trent
Plewes, Katherine
Ishioka, Haruhiko
Leopold, Stije J.
Sinha, Ipsita
Intharabut, Benjamas
Piera, Kim
McNeil, Yvette
Mohanty, Sanjib
Maude, Richard J.
White, Nicholas J.
Day, Nicholas P. J.
Yeo, Tsin Wen
Md Amir Hossain
Anstey, Nicholas M.
Dondorp, Arjen M.
Keywords: Science::Medicine
Issue Date: 2020
Source: Kingston, H. W. F., Ghose, A., Rungpradubvong, V., Satitthummanid, S., Herdman, M. T., Plewes, K., Ishioka, H., Leopold, S. J., Sinha, I., Intharabut, B., Piera, K., McNeil, Y., Mohanty, S., Maude, R. J., White, N. J., Day, N. P. J., Yeo, T. W., Md Amir Hossain, Anstey, N. M. & Dondorp, A. M. (2020). Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria. Journal of Infectious Diseases, 221(1), 127-137.
Journal: Journal of Infectious Diseases
Abstract: In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria.
ISSN: 0022-1899
DOI: 10.1093/infdis/jiz359
Rights: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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