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https://hdl.handle.net/10356/152850| Title: | Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria | Authors: | Kingston, Hugh W. F. Ghose, Aniruddha Rungpradubvong, Voravut Satitthummanid, Sudarat Herdman, M. Trent Plewes, Katherine Ishioka, Haruhiko Leopold, Stije J. Sinha, Ipsita Intharabut, Benjamas Piera, Kim McNeil, Yvette Mohanty, Sanjib Maude, Richard J. White, Nicholas J. Day, Nicholas P. J. Yeo, Tsin Wen Md Amir Hossain Anstey, Nicholas M. Dondorp, Arjen M. |
Keywords: | Science::Medicine | Issue Date: | 2020 | Source: | Kingston, H. W. F., Ghose, A., Rungpradubvong, V., Satitthummanid, S., Herdman, M. T., Plewes, K., Ishioka, H., Leopold, S. J., Sinha, I., Intharabut, B., Piera, K., McNeil, Y., Mohanty, S., Maude, R. J., White, N. J., Day, N. P. J., Yeo, T. W., Md Amir Hossain, Anstey, N. M. & Dondorp, A. M. (2020). Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria. Journal of Infectious Diseases, 221(1), 127-137. https://dx.doi.org/10.1093/infdis/jiz359 | Journal: | Journal of Infectious Diseases | Abstract: | In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria. | URI: | https://hdl.handle.net/10356/152850 | ISSN: | 0022-1899 | DOI: | 10.1093/infdis/jiz359 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Rights: | © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | LKCMedicine Journal Articles |
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| jiz359.pdf | 268.5 kB | Adobe PDF |  View/Open |
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