Please use this identifier to cite or link to this item:
Title: Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface
Authors: Li, Yuanzhe
Li, Xiang
Hao, Yu
Liu, Yang
Dong, ZhiLi
Li, Kexin
Keywords: Engineering::Materials
Issue Date: 2021
Source: Li, Y., Li, X., Hao, Y., Liu, Y., Dong, Z. & Li, K. (2021). Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface. International Journal of Biological Sciences, 17(7), 1769-1781.
Project: Call 1/2018
EP Code EP5P
Journal: International Journal of Biological Sciences
Abstract: The formation of biofilms on medical-context surfaces gives the EPS embedded bacterial community protection and additional advantages that planktonic cells would not have such as increased antibiotic resistance and horizontal gene transfer. Bacterial cells tend to attach to a conditioning layer after overcoming possible electrical barriers and go through two phases of attachments: reversible and irreversible. In the first, bacterial attachment to the surface is reversible and occurs quickly whilst the latter is permanent and takes place over a longer period of time. Upon reaching a certain density in the bacterial community, quorum sensing causes phenotypical changes leading to a loss in motility and the production of EPS. This position paper seeks to address the problem of bacterial adhesion and biofilm formation for the medical surfaces by comparing inhabiting physicochemical interactions and biological mechanisms. Several physiochemical methodologies (e.g. ultrasonication, alternating magnetic field and chemical surface coating) and utilizing biological mechanisms (e.g. quorum quenching and EPS degrading enzymes) were suggested. The possible strategical applications of each category were suggested and evaluated to a balanced position to possibly eliminate the adhesion and formation of biofilms on medical-context surfaces.
ISSN: 1449-2288
DOI: 10.7150/ijbs.59025
Rights: © 2021 The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ( See for full terms and conditions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

Files in This Item:
File Description SizeFormat 
v17p1769.pdf1.25 MBAdobe PDFView/Open

Page view(s)

Updated on May 28, 2022

Download(s) 50

Updated on May 28, 2022

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.