Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/152923
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dc.contributor.authorLi, Yuanzheen_US
dc.contributor.authorLi, Xiangen_US
dc.contributor.authorHao, Yuen_US
dc.contributor.authorLiu, Yangen_US
dc.contributor.authorDong, ZhiLien_US
dc.contributor.authorLi, Kexinen_US
dc.date.accessioned2021-10-21T04:34:27Z-
dc.date.available2021-10-21T04:34:27Z-
dc.date.issued2021-
dc.identifier.citationLi, Y., Li, X., Hao, Y., Liu, Y., Dong, Z. & Li, K. (2021). Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface. International Journal of Biological Sciences, 17(7), 1769-1781. https://dx.doi.org/10.7150/ijbs.59025en_US
dc.identifier.issn1449-2288en_US
dc.identifier.urihttps://hdl.handle.net/10356/152923-
dc.description.abstractThe formation of biofilms on medical-context surfaces gives the EPS embedded bacterial community protection and additional advantages that planktonic cells would not have such as increased antibiotic resistance and horizontal gene transfer. Bacterial cells tend to attach to a conditioning layer after overcoming possible electrical barriers and go through two phases of attachments: reversible and irreversible. In the first, bacterial attachment to the surface is reversible and occurs quickly whilst the latter is permanent and takes place over a longer period of time. Upon reaching a certain density in the bacterial community, quorum sensing causes phenotypical changes leading to a loss in motility and the production of EPS. This position paper seeks to address the problem of bacterial adhesion and biofilm formation for the medical surfaces by comparing inhabiting physicochemical interactions and biological mechanisms. Several physiochemical methodologies (e.g. ultrasonication, alternating magnetic field and chemical surface coating) and utilizing biological mechanisms (e.g. quorum quenching and EPS degrading enzymes) were suggested. The possible strategical applications of each category were suggested and evaluated to a balanced position to possibly eliminate the adhesion and formation of biofilms on medical-context surfaces.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationCall 1/2018en_US
dc.relationEP Code EP5Pen_US
dc.relation122018-T1-001-077en_US
dc.relation.ispartofInternational Journal of Biological Sciencesen_US
dc.rights© 2021 The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.en_US
dc.subjectEngineering::Materialsen_US
dc.titleBiological and physiochemical methods of biofilm adhesion resistance control of medical-context surfaceen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doi10.7150/ijbs.59025-
dc.description.versionPublished versionen_US
dc.identifier.pmid33994861-
dc.identifier.scopus2-s2.0-85105951285-
dc.identifier.issue7en_US
dc.identifier.volume17en_US
dc.identifier.spage1769en_US
dc.identifier.epage1781en_US
dc.subject.keywordsBiofilms Adhesionen_US
dc.subject.keywordsMedical-context Surfaceen_US
dc.description.acknowledgementThis research was funded by MOE Academic Research Fund (AcRF) Tier 1 Project “Nanostructured Titania with tunable hydrophilic/ hydrophobic behavior and photocatalytic function for marine structure application”, Grant Call (Call 1/2018) _MSE (EP Code EP5P, Project ID 122018-T1-001-077), Ministry of Education (MOE), Singapore.en_US
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