Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/153154
Title: Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies
Authors: Kong, Jia Wen
Lam, Zhiyong
Chan, Kiat Hwa
Ganguly, Rakesh
Lee, Joey Jia-Ying
Loo, Lit-Hsin
Webster, Richard D.
Wong, Zhen Xuan
Leong, Weng Kee
Keywords: Science::Chemistry
Issue Date: 2021
Source: Kong, J. W., Lam, Z., Chan, K. H., Ganguly, R., Lee, J. J., Loo, L., Webster, R. D., Wong, Z. X. & Leong, W. K. (2021). Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies. ACS Omega, 6(43), 29045-29053. https://dx.doi.org/10.1021/acsomega.1c04116
Project: RG121/18
Journal: ACS Omega
Abstract: A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.
URI: https://hdl.handle.net/10356/153154
ISSN: 2470-1343
DOI: 10.1021/acsomega.1c04116
Schools: School of Physical and Mathematical Sciences 
Rights: © 2021 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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