Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/15346
Title: | A film prototype for ocular delivery | Authors: | Wang, Anthony Zhen An | Keywords: | DRNTU::Engineering::Materials::Biomaterials | Issue Date: | 2009 | Abstract: | The use of shape memory effect in biomedical devices to treat ocular disease such as glaucoma is increasingly popular. The device can be inserted into the eye with a low shape profile, before being allowed to expand to a desired shape at the site of application. This study focuses on the synthesis of a device using a biodegradable polymer film, poly(lactide-co-glycolide) (PLGA). Several parameters were investigated by correlating their influence on the shape memory characteristic of PLGA 53/47. To quantify the recovery of the temporary deformed film, thermomechanical cycle and bending test methods were adopted. The effects of deformation stress, temperature and duration, processing methods and shape-setting duration were evaluated. High deformation stress at lower deformation temperature for a short duration will yield a higher recovery of the temporary deformed film. Permanent shape of the polymer can be induce by heating it above its glass transition temperature and curved into its shape for a sufficient time. Solution-cast PLGA 53/47 also exhibit better shape memory behavior than the compression-mold one. Generally, the effects of these parameters on the shape memory behavior can be explained in the basis of molecular orientation, slippage effects and thermodynamics aspects. | URI: | http://hdl.handle.net/10356/15346 | Schools: | School of Materials Science and Engineering | Rights: | Nanyang Technological University | Fulltext Permission: | restricted | Fulltext Availability: | With Fulltext |
Appears in Collections: | MSE Student Reports (FYP/IA/PA/PI) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Microsoft Word - final report_cp.pdf Restricted Access | 997.91 kB | Adobe PDF | View/Open |
Page view(s) 50
479
Updated on Mar 27, 2024
Download(s) 50
22
Updated on Mar 27, 2024
Google ScholarTM
Check
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.