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Title: A film prototype for ocular delivery
Authors: Wang, Anthony Zhen An
Keywords: DRNTU::Engineering::Materials::Biomaterials
Issue Date: 2009
Abstract: The use of shape memory effect in biomedical devices to treat ocular disease such as glaucoma is increasingly popular. The device can be inserted into the eye with a low shape profile, before being allowed to expand to a desired shape at the site of application. This study focuses on the synthesis of a device using a biodegradable polymer film, poly(lactide-co-glycolide) (PLGA). Several parameters were investigated by correlating their influence on the shape memory characteristic of PLGA 53/47. To quantify the recovery of the temporary deformed film, thermomechanical cycle and bending test methods were adopted. The effects of deformation stress, temperature and duration, processing methods and shape-setting duration were evaluated. High deformation stress at lower deformation temperature for a short duration will yield a higher recovery of the temporary deformed film. Permanent shape of the polymer can be induce by heating it above its glass transition temperature and curved into its shape for a sufficient time. Solution-cast PLGA 53/47 also exhibit better shape memory behavior than the compression-mold one. Generally, the effects of these parameters on the shape memory behavior can be explained in the basis of molecular orientation, slippage effects and thermodynamics aspects.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:MSE Student Reports (FYP/IA/PA/PI)

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