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Title: Anticancer potential of L-histidine-capped silver nanoparticles against human cervical cancer cells (SIHA)
Authors: Mohammed Asik, Rajmohamed
Manikkaraja, Chidhambaram
Tamil Surya, Karuppusamy
Suganthy, Natarajan
Priya Aarthy, Archunan
Mathe, Domokos
Sivakumar, Muthusamy
Archunan, Govindaraju
Padmanabhan, Parasuraman
Gulyás, Balázs
Keywords: Science::Medicine
Issue Date: 2021
Source: Mohammed Asik, R., Manikkaraja, C., Tamil Surya, K., Suganthy, N., Priya Aarthy, A., Mathe, D., Sivakumar, M., Archunan, G., Padmanabhan, P. & Gulyás, B. (2021). Anticancer potential of L-histidine-capped silver nanoparticles against human cervical cancer cells (SIHA). Nanomaterials, 11(11), 3154-.
Project: ADH-11/2017-DSAIR
Journal: Nanomaterials
Abstract: This study reports the synthesis of silver nanoparticles using amino acid L-histidine as a reducing and capping agent as an eco-friendly approach. Fabricated L-histidine-capped silver nanoparticles (L-HAgNPs) were characterized by spectroscopic and microscopic studies. Spherical shaped L-HAgNPs were synthesized with a particle size of 47.43 ± 19.83 nm and zeta potential of -20.5 ± 0.95 mV. Results of the anticancer potential of L-HAgNPs showed antiproliferative effect against SiHa cells in a dose-dependent manner with an IC50 value of 18.25 ± 0.36 µg/mL. Fluorescent microscopic analysis revealed L-HAgNPs induced reactive oxygen species (ROS) mediated mitochondrial dysfunction, leading to activation of apoptotic pathway and DNA damage eventually causing cell death. To conclude, L-HAgNPs can act as promising candidates for cervical cancer therapy.
ISSN: 2079-4991
DOI: 10.3390/nano11113154
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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