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DC Field | Value | Language |
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dc.contributor.author | Mohammed Asik, Rajmohamed | en_US |
dc.contributor.author | Manikkaraja, Chidhambaram | en_US |
dc.contributor.author | Tamil Surya, Karuppusamy | en_US |
dc.contributor.author | Suganthy, Natarajan | en_US |
dc.contributor.author | Priya Aarthy, Archunan | en_US |
dc.contributor.author | Mathe, Domokos | en_US |
dc.contributor.author | Sivakumar, Muthusamy | en_US |
dc.contributor.author | Archunan, Govindaraju | en_US |
dc.contributor.author | Padmanabhan, Parasuraman | en_US |
dc.contributor.author | Gulyás, Balázs | en_US |
dc.date.accessioned | 2021-12-06T03:01:20Z | - |
dc.date.available | 2021-12-06T03:01:20Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Mohammed Asik, R., Manikkaraja, C., Tamil Surya, K., Suganthy, N., Priya Aarthy, A., Mathe, D., Sivakumar, M., Archunan, G., Padmanabhan, P. & Gulyás, B. (2021). Anticancer potential of L-histidine-capped silver nanoparticles against human cervical cancer cells (SIHA). Nanomaterials, 11(11), 3154-. https://dx.doi.org/10.3390/nano11113154 | en_US |
dc.identifier.issn | 2079-4991 | en_US |
dc.identifier.uri | https://hdl.handle.net/10356/153510 | - |
dc.description.abstract | This study reports the synthesis of silver nanoparticles using amino acid L-histidine as a reducing and capping agent as an eco-friendly approach. Fabricated L-histidine-capped silver nanoparticles (L-HAgNPs) were characterized by spectroscopic and microscopic studies. Spherical shaped L-HAgNPs were synthesized with a particle size of 47.43 ± 19.83 nm and zeta potential of -20.5 ± 0.95 mV. Results of the anticancer potential of L-HAgNPs showed antiproliferative effect against SiHa cells in a dose-dependent manner with an IC50 value of 18.25 ± 0.36 µg/mL. Fluorescent microscopic analysis revealed L-HAgNPs induced reactive oxygen species (ROS) mediated mitochondrial dysfunction, leading to activation of apoptotic pathway and DNA damage eventually causing cell death. To conclude, L-HAgNPs can act as promising candidates for cervical cancer therapy. | en_US |
dc.description.sponsorship | Nanyang Technological University | en_US |
dc.language.iso | en | en_US |
dc.relation | ADH-11/2017-DSAIR | en_US |
dc.relation.ispartof | Nanomaterials | en_US |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | en_US |
dc.subject | Science::Medicine | en_US |
dc.title | Anticancer potential of L-histidine-capped silver nanoparticles against human cervical cancer cells (SIHA) | en_US |
dc.type | Journal Article | en |
dc.contributor.school | Lee Kong Chian School of Medicine (LKCMedicine) | en_US |
dc.contributor.research | Cognitive Neuroimaging Centre | en_US |
dc.identifier.doi | 10.3390/nano11113154 | - |
dc.description.version | Published version | en_US |
dc.identifier.pmid | 34835918 | - |
dc.identifier.scopus | 2-s2.0-85119612880 | - |
dc.identifier.issue | 11 | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.spage | 3154 | en_US |
dc.subject.keywords | Anticancer Activity | en_US |
dc.subject.keywords | L-Histidine | en_US |
dc.description.acknowledgement | R.M.A. thanks Science and Engineering Research Board and Indian Council of Medical Research, New Delhi, India, for providing financial support through SERB—Overseas Visiting Doctoral Fellowship (ODF/2018/001044) and Senior Research Fellow (No. 2017-2853/SCRTBMS). N.S. thanks the University Grants Commission, New Delhi, India, for the financial support through the UGC-Start-Up Grant (Ref. No. F. 30-381/2017 (BSR), dated 6 July 2017) and RUSA—Phase 2.0 grant (No. F. 24-51/2014-U, Policy (TNMulti-Gen), Dept. of Edn. Govt. of India, dated 9 October 2018). D.M. thanks to European Union’s Horizon 2020 research and innovation program under grant agreement No 739593. HCEMM supported by EU Program: H2020-EU.4.a. This work was also partly funded by a grant from the Hungarian National Research, Development and Innovation Office (Thematic Excellence Program, TKP-BIOImaging, financed under the 2020-4.1.1-TKP2020 funding scheme). B.G. and P.P. thank Data Science and AI Research (DSAIR) Centre of NTU (Project Number ADH-11/2017-DSAIR), Imaging Probe Development Platform (IPDP), and the support from the Cognitive NeuroImaging Centre (CONIC) at NTU. G.A. acknowledges University Grants Commission, New Delhi, India, for the award of UGC-BSR Faculty Fellow (No. F.18-1/2011(BSR) dt. 4 January 2017). P.P. and B.G. acknowledge the support from Lee Kong Chian School of Medicine and Nanyang Technological University, Singapore. | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
Appears in Collections: | LKCMedicine Journal Articles |
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nanomaterials-11-03154.pdf | 5.78 MB | Adobe PDF | View/Open |
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