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dc.contributor.authorMohammed Asik, Rajmohameden_US
dc.contributor.authorManikkaraja, Chidhambaramen_US
dc.contributor.authorTamil Surya, Karuppusamyen_US
dc.contributor.authorSuganthy, Natarajanen_US
dc.contributor.authorPriya Aarthy, Archunanen_US
dc.contributor.authorMathe, Domokosen_US
dc.contributor.authorSivakumar, Muthusamyen_US
dc.contributor.authorArchunan, Govindarajuen_US
dc.contributor.authorPadmanabhan, Parasuramanen_US
dc.contributor.authorGulyás, Balázsen_US
dc.date.accessioned2021-12-06T03:01:20Z-
dc.date.available2021-12-06T03:01:20Z-
dc.date.issued2021-
dc.identifier.citationMohammed Asik, R., Manikkaraja, C., Tamil Surya, K., Suganthy, N., Priya Aarthy, A., Mathe, D., Sivakumar, M., Archunan, G., Padmanabhan, P. & Gulyás, B. (2021). Anticancer potential of L-histidine-capped silver nanoparticles against human cervical cancer cells (SIHA). Nanomaterials, 11(11), 3154-. https://dx.doi.org/10.3390/nano11113154en_US
dc.identifier.issn2079-4991en_US
dc.identifier.urihttps://hdl.handle.net/10356/153510-
dc.description.abstractThis study reports the synthesis of silver nanoparticles using amino acid L-histidine as a reducing and capping agent as an eco-friendly approach. Fabricated L-histidine-capped silver nanoparticles (L-HAgNPs) were characterized by spectroscopic and microscopic studies. Spherical shaped L-HAgNPs were synthesized with a particle size of 47.43 ± 19.83 nm and zeta potential of -20.5 ± 0.95 mV. Results of the anticancer potential of L-HAgNPs showed antiproliferative effect against SiHa cells in a dose-dependent manner with an IC50 value of 18.25 ± 0.36 µg/mL. Fluorescent microscopic analysis revealed L-HAgNPs induced reactive oxygen species (ROS) mediated mitochondrial dysfunction, leading to activation of apoptotic pathway and DNA damage eventually causing cell death. To conclude, L-HAgNPs can act as promising candidates for cervical cancer therapy.en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relationADH-11/2017-DSAIRen_US
dc.relation.ispartofNanomaterialsen_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en_US
dc.subjectScience::Medicineen_US
dc.titleAnticancer potential of L-histidine-capped silver nanoparticles against human cervical cancer cells (SIHA)en_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.researchCognitive Neuroimaging Centreen_US
dc.identifier.doi10.3390/nano11113154-
dc.description.versionPublished versionen_US
dc.identifier.pmid34835918-
dc.identifier.scopus2-s2.0-85119612880-
dc.identifier.issue11en_US
dc.identifier.volume11en_US
dc.identifier.spage3154en_US
dc.subject.keywordsAnticancer Activityen_US
dc.subject.keywordsL-Histidineen_US
dc.description.acknowledgementR.M.A. thanks Science and Engineering Research Board and Indian Council of Medical Research, New Delhi, India, for providing financial support through SERB—Overseas Visiting Doctoral Fellowship (ODF/2018/001044) and Senior Research Fellow (No. 2017-2853/SCRTBMS). N.S. thanks the University Grants Commission, New Delhi, India, for the financial support through the UGC-Start-Up Grant (Ref. No. F. 30-381/2017 (BSR), dated 6 July 2017) and RUSA—Phase 2.0 grant (No. F. 24-51/2014-U, Policy (TNMulti-Gen), Dept. of Edn. Govt. of India, dated 9 October 2018). D.M. thanks to European Union’s Horizon 2020 research and innovation program under grant agreement No 739593. HCEMM supported by EU Program: H2020-EU.4.a. This work was also partly funded by a grant from the Hungarian National Research, Development and Innovation Office (Thematic Excellence Program, TKP-BIOImaging, financed under the 2020-4.1.1-TKP2020 funding scheme). B.G. and P.P. thank Data Science and AI Research (DSAIR) Centre of NTU (Project Number ADH-11/2017-DSAIR), Imaging Probe Development Platform (IPDP), and the support from the Cognitive NeuroImaging Centre (CONIC) at NTU. G.A. acknowledges University Grants Commission, New Delhi, India, for the award of UGC-BSR Faculty Fellow (No. F.18-1/2011(BSR) dt. 4 January 2017). P.P. and B.G. acknowledge the support from Lee Kong Chian School of Medicine and Nanyang Technological University, Singapore.en_US
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